控制大肠杆菌中酪氨酸生物合成相关酶的调节基因。
Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli.
作者信息
Wallace B J, Pittard J
出版信息
J Bacteriol. 1969 Mar;97(3):1234-41. doi: 10.1128/jb.97.3.1234-1241.1969.
Abstract
Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR.
摘要
已分离出大肠杆菌K-12的突变体，其中几种与酪氨酸生物合成有关的酶被去阻遏。这些突变体是从仅拥有一种3-脱氧-D-阿拉伯庚酮糖酸-7-磷酸（DAHP）合成酶同工酶，即DAHP合成酶（tyr）的亲本菌株中，通过筛选对酪氨酸类似物4-氨基苯丙氨酸的抗性而获得的。导致这种去阻遏的突变已被定位，且该基因与aroF和tyrA没有紧密连锁，已被命名为tyrR。
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Genetic and biochemical analysis of the isoenzymes concerned in the first reaction of aromatic biosynthesis in Escherichia coli.大肠杆菌中芳香族生物合成第一步反应所涉及的同工酶的遗传与生化分析。
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