控制大肠杆菌中酪氨酸生物合成相关酶的调节基因。
Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli.
作者信息
Wallace B J, Pittard J
出版信息
J Bacteriol. 1969 Mar;97(3):1234-41. doi: 10.1128/jb.97.3.1234-1241.1969.
Abstract
Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR.
摘要
已分离出大肠杆菌K-12的突变体，其中几种与酪氨酸生物合成有关的酶被去阻遏。这些突变体是从仅拥有一种3-脱氧-D-阿拉伯庚酮糖酸-7-磷酸（DAHP）合成酶同工酶，即DAHP合成酶（tyr）的亲本菌株中，通过筛选对酪氨酸类似物4-氨基苯丙氨酸的抗性而获得的。导致这种去阻遏的突变已被定位，且该基因与aroF和tyrA没有紧密连锁，已被命名为tyrR。
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