Lee P L, Murthy V S
Clin Exp Hypertens (1978). 1979;1(5):685-701. doi: 10.3109/10641967909068632.
Intravenous administration of arachidonic acid lowers systemic arterial pressure in conscious and anesthetized rabbits. This hypotensive response does not show tachyphylaxis and is blocked by aspirin. The hypotension on i.v. administration is due to both a decrease in cardiac output and a decrease in systemic vascular resistance. The decrease in cardiac output is accompanied by a severe pulmonary hypertension and right ventricular failure. Upon i.a. arachidonic acid administration, the hypotension is due to a decrease in systemic vascular resistance. It is proposed that arachidonic acid is transformed predominantly into a vasoconstrictor metabolite in the pulmonary vascular bed and vasodilator metabolite in the systemic vascular bed. The nature of the metabolite remains to be established.
静脉注射花生四烯酸可降低清醒和麻醉兔的体循环动脉压。这种降压反应不出现快速耐受性，且可被阿司匹林阻断。静脉注射引起的低血压是由于心输出量减少和体循环血管阻力降低所致。心输出量的减少伴有严重的肺动脉高压和右心室衰竭。腹腔注射花生四烯酸后，低血压是由于体循环血管阻力降低所致。有人提出，花生四烯酸在肺血管床主要转化为血管收缩代谢产物，而在体循环血管床则转化为血管舒张代谢产物。代谢产物的性质尚待确定。
