Gordon D A, Franklin A E, Karstad L
Can Med Assoc J. 1967 May 6;96(18):1245-51.
A disease in mink has been discovered that has many of the features of collagen diseases in man. Affected animals suffer from wasting with leukopenia and thrombocytopenia as well as plasma cell infiltration, hypergammaglobulinemia, glomerulonephritis, arteritis and amyloidosis. Cell-free filtrates and ultracentrifugates from diseased animals induced the disease in normal mink, and aleutian genotypes were unusually susceptible to infection. This genotype was characterized by abnormal lysosomal structures in all the granule-forming cells, resembling the Chediak-Higashi syndrome of man. Anti-gamma-globulin factors similar to human rheumatoid factors were reported, although tests for antibodies such as ANF and LE factors have been negative. Arteritis and glomerulonephritis lesions stained positively for gamma-globulin, and Coombs-type sensitized red cells have been detected in the majority of affected mink. Some mink develop a monodispersion of hypergammaglobulinemia resembling the serum protein changes in human myeloma. These studies highlight genetic, immunological and microbiological causative factors in a mink disorder resembling human collagen disease.
在水貂中发现了一种疾病，它具有许多人类胶原病的特征。患病动物出现消瘦，并伴有白细胞减少、血小板减少，以及浆细胞浸润、高球蛋白血症、肾小球肾炎、动脉炎和淀粉样变性。患病动物的无细胞滤液和超速离心物可使正常水貂感染该病，阿留申基因型对感染异常敏感。该基因型的特征是所有颗粒形成细胞中的溶酶体结构异常，类似于人类的切迪阿克-东综合征。虽然抗核抗体和红斑狼疮因子等抗体检测呈阴性，但已报告存在类似于人类类风湿因子的抗γ球蛋白因子。动脉炎和肾小球肾炎病变的γ球蛋白染色呈阳性，并且在大多数患病水貂中检测到库姆斯型致敏红细胞。一些水貂出现单克隆高球蛋白血症，类似于人类骨髓瘤中的血清蛋白变化。这些研究突出了一种类似于人类胶原病的水貂疾病中的遗传、免疫和微生物致病因素。
