Dawson J, Carr-Locke D L, Talbot I C, Rosenthal F D
Gut. 1979 Oct;20(10):848-53. doi: 10.1136/gut.20.10.848.
Hepatic ultrastructure was examined by electron microscopy in 25 patients with Gilbert's syndrome and the changes in the smooth endoplasmic reticulum quantified by grid technique. Thirteen patients showed gross hypertrophy of the smooth endoplasmic reticulum (SER). These were designated Gilbert's EM Positive. The remaining 12, designated Gilbert's EM Negative, did not differ significantly from normal controls. The EM Positive group showed a significantly greater percentage response to caloric restriction (P less than 0.01) and an exaggerated response to nicotinic acid stimulation when compared with the EM Negative group and normal controls. These results suggest that SER hypertrophy is not, as previously suggested, a constant feature of Gilbert's syndrome but rather a characteristic of a distinct subpopulation.
通过电子显微镜检查了25例吉尔伯特综合征患者的肝脏超微结构，并采用网格技术对滑面内质网的变化进行了量化。13例患者表现出滑面内质网（SER）明显肥大。这些被指定为吉尔伯特综合征电子显微镜阳性。其余12例被指定为吉尔伯特综合征电子显微镜阴性，与正常对照组无显著差异。与电子显微镜阴性组和正常对照组相比，电子显微镜阳性组对热量限制的反应百分比显著更高（P<0.01），对烟酸刺激的反应也更为夸张。这些结果表明，SER肥大并非如先前所述是吉尔伯特综合征的恒定特征，而是一个独特亚群的特征。
