吉尔伯特综合征患者的N-乙酰化和异喹胍羟基化多态性
N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome.
作者信息
Siegmund W, Fengler J D, Franke G, Zschiesche M, Eike O, Eike E, Meisel P, Wulkow R
机构信息
Department of Clinical Pharmacology, University of Greifswald, Germany.
出版信息
Br J Clin Pharmacol. 1991 Oct;32(4):467-72. doi: 10.1111/j.1365-2125.1991.tb03932.x.
Abstract
- N-acetylation and debrisoquine hydroxylation phenotypes were determined in 54 patients with Gilbert's syndrome and in 247 (sulphamethazine) and 76 (debrisoquine) non-related healthy volunteers. 2. Forty (74.1%) of the patients and 135 (54.7%) of the healthy volunteers were slow acetylators (chi 2 = 6.87). In the patients, the cumulative urinary excretion of sulphamethazine up to 6 h (Ae(0,6)) was significantly lower. No differences in the frequency of debrisoquine poor metabolizers were observed: Gilbert's syndrome 5/54 (9.3%), healthy volunteers 5/76 (6.6%). The metabolic ratios were similar in both groups as well as the urinary recoveries of debrisoquine and its 4-hydroxy metabolite. 3. Gilbert's syndrome seems to be related in some way to N-acetylation but not to the debrisoquine hydroxylation polymorphism.
摘要
- 对54例吉尔伯特综合征患者以及247名（涉及磺胺二甲嘧啶）和76名（涉及异喹胍）无关健康志愿者测定了N - 乙酰化和异喹胍羟基化表型。2. 患者中有40例（74.1%）以及健康志愿者中有135例（54.7%）为慢乙酰化者（卡方 = 6.87）。患者中，磺胺二甲嘧啶至6小时的累积尿排泄量（Ae(0,6)）显著更低。在异喹胍代谢不良者的频率上未观察到差异：吉尔伯特综合征患者5/54（9.3%），健康志愿者5/76（6.6%）。两组的代谢率以及异喹胍及其4 - 羟基代谢物的尿回收率相似。3. 吉尔伯特综合征似乎在某种程度上与N - 乙酰化有关，但与异喹胍羟基化多态性无关。
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