局部麻醉药可阻断铜绿假单胞菌alk调节子的诱导。
Local anesthetics block induction of the Pseudomonas alk regulon.
作者信息
Benson S A
出版信息
J Bacteriol. 1979 Dec;140(3):1123-5. doi: 10.1128/jb.140.3.1123-1125.1979.
Abstract
The local anesthetics procaine and piperocaine blocked induction of the plasmid-determined enzymatic activities involved in the metabolism of n-alkanes in Pseudomonas putida. Procaine reversibly inhibited existing alkane hydroxylase activity. Induction of a soluble aliphatic amidase activity was not affected. These results support the hypothesis that induction of the plasmid-determined alkane metabolic system in P. putida involves a membrane component(s).
摘要
局部麻醉药普鲁卡因和哌罗卡因可阻断恶臭假单胞菌中由质粒决定的参与正构烷烃代谢的酶活性的诱导。普鲁卡因可逆性抑制现有的烷烃羟化酶活性。可溶性脂肪族酰胺酶活性的诱导不受影响。这些结果支持了这样一种假说，即恶臭假单胞菌中由质粒决定的烷烃代谢系统的诱导涉及一种膜成分。
相似文献
1
Local anesthetics block induction of the Pseudomonas alk regulon.局部麻醉药可阻断铜绿假单胞菌alk调节子的诱导。
J Bacteriol. 1979 Dec;140(3):1123-5. doi: 10.1128/jb.140.3.1123-1125.1979.
2
Fractionation of inducible alkane hydroxylase activity in Pseudomonas putida and characterization of hydroxylase-negative plasmid mutations.恶臭假单胞菌中诱导型烷烃羟化酶活性的分级分离及羟化酶阴性质粒突变的表征
J Bacteriol. 1977 Nov;132(2):614-21. doi: 10.1128/jb.132.2.614-621.1977.
3
The PalkBFGHJKL promoter is under carbon catabolite repression control in Pseudomonas oleovorans but not in Escherichia coli alk+ recombinants.在食油假单胞菌中，PalkBFGHJKL启动子受碳分解代谢物阻遏控制，但在大肠杆菌alk+重组体中不受此控制。
J Bacteriol. 1999 Mar;181(5):1610-6. doi: 10.1128/JB.181.5.1610-1616.1999.
4
The alkane oxidation system of Pseudomonas oleovorans: induction of the alk genes in Escherichia coli W3110 (pGEc47) affects membrane biogenesis and results in overexpression of alkane hydroxylase in a distinct cytoplasmic membrane subfraction.食油假单胞菌的烷烃氧化系统：在大肠杆菌W3110（pGEc47）中诱导alk基因会影响膜生物合成，并导致烷烃羟化酶在一个独特的细胞质膜亚组分中过表达。
Mol Microbiol. 1993 Jun;8(6):1039-51. doi: 10.1111/j.1365-2958.1993.tb01649.x.
5
Regulatory mutations of the Pseudomonas plasmid alk regulon.铜绿假单胞菌质粒烷烃调控子的调控突变
J Bacteriol. 1977 Nov;132(2):622-7. doi: 10.1128/jb.132.2.622-627.1977.
6
Controlled and functional expression of the Pseudomonas oleovorans alkane utilizing system in Pseudomonas putida and Escherichia coli.食油假单胞菌烷烃利用系统在恶臭假单胞菌和大肠杆菌中的可控功能性表达。
J Biol Chem. 1987 Dec 25;262(36):17712-8.
7
Regulation of membrane peptides by the Pseudomonas plasmid alk regulon.铜绿假单胞菌质粒alk调节子对膜肽的调控
J Bacteriol. 1979 Dec;140(3):754-62. doi: 10.1128/jb.140.3.754-762.1979.
8
Induction of alkane hydroxylase proteins by unoxidized alkane in Pseudomonas putida.恶臭假单胞菌中未氧化烷烃对烷烃羟化酶蛋白的诱导作用。
J Bacteriol. 1975 Aug;123(2):759-60. doi: 10.1128/jb.123.2.759-760.1975.
9
Regulation of alkane oxidation in Pseudomonas putida.恶臭假单胞菌中烷烃氧化的调控
J Bacteriol. 1975 Aug;123(2):546-56. doi: 10.1128/jb.123.2.546-556.1975.
10
Insertion element analysis and mapping of the Pseudomonas plasmid alk regulon.
J Bacteriol. 1979 Sep;139(3):940-52. doi: 10.1128/jb.139.3.940-952.1979.
引用本文的文献
1
Toluene induction and uptake kinetics and their inclusion in the specific-affinity relationship for describing rates of hydrocarbon metabolism.甲苯诱导和摄取动力学及其在描述烃类代谢速率的特异性亲和力关系中的应用。
Appl Environ Microbiol. 1987 Sep;53(9):2193-205. doi: 10.1128/aem.53.9.2193-2205.1987.
2
Selective inhibition of carbohydrate transport by the local anesthetic procaine in Escherichia coli.局部麻醉药普鲁卡因对大肠杆菌碳水化合物转运的选择性抑制作用。
J Bacteriol. 1981 Aug;147(2):289-96. doi: 10.1128/jb.147.2.289-296.1981.
3
Local anesthetics block transient expression of inducible functions for transformation in Streptococcus sanguis.局部麻醉药可阻断血链球菌中诱导性转化功能的瞬时表达。
J Bacteriol. 1983 Oct;156(1):450-4. doi: 10.1128/jb.156.1.450-454.1983.
本文引用的文献
1
Biochemical and genetic studies with regulator mutants of the Pseudomonas aeruginosa 8602 amidase system.对铜绿假单胞菌8602酰胺酶系统调节突变体的生化和遗传学研究。
J Gen Microbiol. 1967 Apr;47(1):87-102. doi: 10.1099/00221287-47-1-87.
2
The membrane actions of anesthetics and tranquilizers.麻醉剂和镇静剂的膜作用。
Pharmacol Rev. 1972 Dec;24(4):583-655.
3
Studies on the mechanism of action of local anesthetics with phospholipid model membranes.利用磷脂模型膜对局部麻醉药作用机制的研究。
Biochim Biophys Acta. 1972 Apr 18;265(2):169-86. doi: 10.1016/0304-4157(72)90001-9.
4
Induction of alkane hydroxylase proteins by unoxidized alkane in Pseudomonas putida.恶臭假单胞菌中未氧化烷烃对烷烃羟化酶蛋白的诱导作用。
J Bacteriol. 1975 Aug;123(2):759-60. doi: 10.1128/jb.123.2.759-760.1975.
5
Regulation of alkane oxidation in Pseudomonas putida.恶臭假单胞菌中烷烃氧化的调控
J Bacteriol. 1975 Aug;123(2):546-56. doi: 10.1128/jb.123.2.546-556.1975.
6
Regulatory mutations of the Pseudomonas plasmid alk regulon.铜绿假单胞菌质粒烷烃调控子的调控突变
J Bacteriol. 1977 Nov;132(2):622-7. doi: 10.1128/jb.132.2.622-627.1977.
7
Fractionation of inducible alkane hydroxylase activity in Pseudomonas putida and characterization of hydroxylase-negative plasmid mutations.恶臭假单胞菌中诱导型烷烃羟化酶活性的分级分离及羟化酶阴性质粒突变的表征
J Bacteriol. 1977 Nov;132(2):614-21. doi: 10.1128/jb.132.2.614-621.1977.
8
Induction of alkaline phosphatase in Escherichia coli: effect of procaine hydrochloride.大肠杆菌中碱性磷酸酶的诱导：盐酸普鲁卡因的作用
J Bacteriol. 1977 Aug;131(2):431-7. doi: 10.1128/jb.131.2.431-437.1977.
9
Plasmid-determined alcohol dehydrogenase activity in alkane-utilizing strains of Pseudomonas putida.恶臭假单胞菌利用烷烃菌株中质粒决定的乙醇脱氢酶活性
J Bacteriol. 1976 May;126(2):794-8. doi: 10.1128/jb.126.2.794-798.1976.
10
Depression of phase-transition temperature in a model cell membrane by local anesthetics.局部麻醉药对模型细胞膜相变温度的降低作用。
Anesthesiology. 1977 May;46(5):327-32. doi: 10.1097/00000542-197705000-00004.
Zotero 插件