长期抗高血压治疗对自发性高血压大鼠双侧颈动脉闭塞后脑代谢的影响。
Effects of long-term antihypertensive treatment on brain metabolism after bilateral carotid artery occlusion in spontaneously hypertensive rats.
作者信息
Tamaki K, Fujishima M, Nakatomi Y, Ishitsuka T, Ogata J, Omae T
出版信息
J Neurol Neurosurg Psychiatry. 1979 Dec;42(12):1141-5. doi: 10.1136/jnnp.42.12.1141.
Abstract
The effects of antihypertensive treatment on brain metabolism after bilateral carotid occlusion were studied in spontaneously hypertensive rats. The results indicate that an increase in metabolites of ischaemic brain such as lactate and the lactate/pyruvate ratio after carotid occlusion in spontaneously hypertensive rats is apparently suppressed by treating hypertension. This suggests that hypertension may play an important role in susceptibility to cerebral ischaemia.
摘要
在自发性高血压大鼠中研究了抗高血压治疗对双侧颈动脉闭塞后脑代谢的影响。结果表明，自发性高血压大鼠颈动脉闭塞后缺血性脑代谢产物如乳酸和乳酸/丙酮酸比值的增加通过治疗高血压明显受到抑制。这表明高血压可能在脑缺血易感性中起重要作用。
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本文引用的文献
1
Development of a strain of spontaneously hypertensive rats.一种自发性高血压大鼠品系的培育
Jpn Circ J. 1963 Mar;27:282-93. doi: 10.1253/jcj.27.282.
2
Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats.自发性高血压大鼠血流阻力增加和血管反应性增强的背景。
Acta Physiol Scand. 1970 Sep;80(1):93-106. doi: 10.1111/j.1748-1716.1970.tb04773.x.
3
Structurally based increase of flow resistance in spontaneously hypertensive rats.自发性高血压大鼠基于结构的血流阻力增加。
Acta Physiol Scand. 1970 Jul;79(3):373-8. doi: 10.1111/j.1748-1716.1970.tb04737.x.
4
The hemodynamic consequences of regional hypotension in spontaneously hypertensive and normotensive rats.
Acta Physiol Scand. 1971 Dec;83(4):532-41. doi: 10.1111/j.1748-1716.1971.tb05111.x.
5
The effect of intense treatment with hypotensive drugs on structural design of the resistance vessels in spontaneously hypertensive rats.
Acta Physiol Scand. 1971 Oct;83(2):280-2. doi: 10.1111/j.1748-1716.1971.tb05078.x.
6
Long-term treatment with antihypertensive drugs in spontaneously hypertensive rats (SHR). Effects on blood pressure, survival rate and cardiovascular design.
Acta Physiol Scand. 1974 Jul;91(3):393-408. doi: 10.1111/j.1748-1716.1974.tb05694.x.
7
Vascular resistance and reactivity in hypertensive rats.
Blood Vessels. 1974;11(3):145-58. doi: 10.1159/000158008.
8
Neurogenic and humoral factors controlling vascular resistance in the spontaneously hypertensive rat.控制自发性高血压大鼠血管阻力的神经源性和体液性因素。
Circ Res. 1974 Nov;35(5):764-74. doi: 10.1161/01.res.35.5.764.
9
Effect of increasing age on hemodynamics of spontaneously hypertensive rats.
Jpn Heart J. 1975 May;16(3):257-64. doi: 10.1536/ihj.16.257.
10
Effects of bilateral carotid artery ligation on brain lactate and pyruvate concentrations in normotensive and spontaneously hypertensive rats.
Stroke. 1975 Jan-Feb;6(1):62-6. doi: 10.1161/01.str.6.1.62.
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