Tanaka S, Ashida S, Akashi A
Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Jpn J Pharmacol. 1990 Aug;53(4):502-5. doi: 10.1254/jjp.53.502.
The effects of antihypertensive drugs on ischemic cerebral damage were investigated using the bilateral carotid artery occlusion (BCAO) model in SHR. Oral budralazine and nifedipine, at doses that increased cerebral blood flow (CBF) in SHR in our previous study (Tanaka, S. et al., Folia Pharmacol, Japan, 87, 1986), significantly improved cerebral energy failure after the BCAO, but prazosin which does not increase CBF had no effect on the energy failure. These results suggest that the amelioration by these antihypertensive drugs of the energy failure after the BCAO results from its CBF-increasing effects in SHR.
使用自发性高血压大鼠（SHR）的双侧颈动脉闭塞（BCAO）模型，研究了抗高血压药物对缺血性脑损伤的影响。在我们之前的研究中（Tanaka, S.等人，《日本药理学杂志》，87卷，1986年），口服布屈嗪和硝苯地平，在能增加SHR脑血流量（CBF）的剂量下，显著改善了BCAO后的脑能量衰竭，但不增加CBF的哌唑嗪对能量衰竭没有影响。这些结果表明，这些抗高血压药物对BCAO后能量衰竭的改善是由于其在SHR中增加CBF的作用。
