Weir A, Hansen S, Ballantyne J P
J Neurol Neurosurg Psychiatry. 1979 Dec;42(12):1146-50. doi: 10.1136/jnnp.42.12.1146.
Recent histological and electrophysiological reports have given evidence for peripheral nervous system (PNS) involvement in multiple sclerosis. We have applied the single fibre electromyography (SFEMG) technique to 15 patients with multiple sclerosis. Six patients had clearly abnormal jitter and two of these had previously undiagnosed coexistent peripheral neuropathy. A further five patients had borderline abnormalities of SFEMG. The mean jitter for each patient was abnormal in 10 patients. This was clear evidence for PNS involvement in this disease. Theoretically, the site of the abnormality could be in the terminal nerve network or at the neuromuscular junction, but this technique cannot distinguish between these sites.
近期的组织学和电生理学报告已为多发性硬化症累及周围神经系统(PNS)提供了证据。我们对15例多发性硬化症患者应用了单纤维肌电图(SFEMG)技术。6例患者有明显异常的颤抖,其中2例之前未被诊断出并存周围神经病变。另有5例患者的SFEMG有临界异常。10例患者的每位患者平均颤抖均异常。这是PNS累及该疾病的明确证据。理论上,异常部位可能在终末神经网络或神经肌肉接头处,但该技术无法区分这些部位。