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1
Two L-asparaginases from E. coli and their action against tumors.来自大肠杆菌的两种L-天冬酰胺酶及其抗肿瘤作用。
Proc Natl Acad Sci U S A. 1966 Nov;56(5):1516-9. doi: 10.1073/pnas.56.5.1516.
2
Factors which may influence the effectiveness of L-asparaginases as tumor inhibitors.可能影响L-天冬酰胺酶作为肿瘤抑制剂有效性的因素。
Br J Cancer. 1968 Sep;22(3):595-602. doi: 10.1038/bjc.1968.71.
3
Increased antitumor activity of Escherichia coli. L-asparaginase by modification with monomethoxypolyethylene glycol.通过单甲氧基聚乙二醇修饰提高大肠杆菌L-天冬酰胺酶的抗肿瘤活性。
Gan. 1982 Jun;73(3):470-4.
4
Two L-asparaginases from Escherichia coli B. Their separation, purification, and antitumor activity.来自大肠杆菌B的两种L-天冬酰胺酶。它们的分离、纯化及抗肿瘤活性。
Biochemistry. 1967 Mar;6(3):721-30. doi: 10.1021/bi00855a011.
5
Treatment of lymphosarcoma in the dog with L-asparaginase.
Cancer. 1967 Jul;20(7):1066-70. doi: 10.1002/1097-0142(196707)20:7<1066::aid-cncr2820200709>3.0.co;2-m.
6
A new L-asparaginase with antitumour activity?一种具有抗肿瘤活性的新型L-天冬酰胺酶？
Lancet. 1968 Oct 5;2(7571):776-7. doi: 10.1016/s0140-6736(68)90977-x.
7
Response of intracerebral Gardner lymphoma to guinea pig L-asparaginase and Escherichia coli L-asparaginase.脑内加德纳淋巴瘤对豚鼠L-天冬酰胺酶和大肠杆菌L-天冬酰胺酶的反应。
Proc Soc Exp Biol Med. 1966 Oct;123(1):133-7. doi: 10.3181/00379727-123-31422.
8
Antagonism of purified asparaginase from guinea pig serum toward lymphoma.豚鼠血清中纯化的天冬酰胺酶对淋巴瘤的拮抗作用。
Science. 1966 Feb 25;151(3713):998-9. doi: 10.1126/science.151.3713.998.
9
L-Asparaginase: discovery and development as a tumor-inhibitory agent.L-天冬酰胺酶：作为一种肿瘤抑制药物的发现与研发
Cancer Treat Rep. 1981;65 Suppl 4:111-4.
10
Localization of the two-L-asparaginases in anaerobically grown Escherichia coli.
J Biol Chem. 1967 Aug 25;242(16):3753-5.

引用本文的文献

1
L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.L-天冬酰胺酶是一种PAR2 N端蛋白酶，可暴露PAR2的拴系配体。
Cell Death Discov. 2025 Apr 8;11(1):152. doi: 10.1038/s41420-025-02467-z.
2
Genetic mutation in genome during adaptation to the murine intestine is optimized for the host diet.在适应小鼠肠道的过程中，基因组中的基因突变会根据宿主饮食进行优化。
mSystems. 2024 Feb 20;9(2):e0112323. doi: 10.1128/msystems.01123-23. Epub 2024 Jan 11.
3
L-Asparaginase from Produced by a Recombinant Strain.由重组菌株产生的L-天冬酰胺酶。
Pharmaceuticals (Basel). 2022 Jun 14;15(6):746. doi: 10.3390/ph15060746.
4
Clinical Utility of Pegaspargase in Children, Adolescents and Young Adult Patients with Acute Lymphoblastic Leukemia: A Review.培门冬酶在儿童、青少年和年轻成年急性淋巴细胞白血病患者中的临床应用：综述
Blood Lymphat Cancer. 2021 Apr 19;11:25-40. doi: 10.2147/BLCTT.S245210. eCollection 2021.
5
Recent Strategies and Applications for l-Asparaginase Confinement.近期 l-天冬酰胺酶的固定化策略及应用。
Molecules. 2020 Dec 10;25(24):5827. doi: 10.3390/molecules25245827.
6
Screening for Type II L-Asparaginases: Lessons from the Genus .II型天冬酰胺酶的筛选：来自该属的经验教训
Iran J Pharm Res. 2017 Fall;16(4):1565-1573.
7
Discovery of human-like L-asparaginases with potential clinical use by directed evolution.通过定向进化发现具有潜在临床应用价值的类人 L-天冬酰胺酶。
Sci Rep. 2017 Aug 31;7(1):10224. doi: 10.1038/s41598-017-10758-4.
8
Purification, Characterization and Comparison between Two New L-asparaginases from PG03 and PG04.来自PG03和PG04的两种新型L-天冬酰胺酶的纯化、表征及比较
Open Biochem J. 2016 Nov 4;10:35-45. doi: 10.2174/1874091X01610010035. eCollection 2016.
9
Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity.酿酒酵母源重组 L-天冬酰胺酶 1：一种具有抗肿瘤活性的别构酶。
Sci Rep. 2016 Nov 8;6:36239. doi: 10.1038/srep36239.
10
L-asparaginase in the treatment of patients with acute lymphoblastic leukemia.L-天冬酰胺酶治疗急性淋巴细胞白血病患者
J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):62-71. doi: 10.4103/0976-500X.184769.

本文引用的文献

1
Characteristics and stabilization of DNAase-sensitive protein synthesis in E. coli extracts.大肠杆菌提取物中脱氧核糖核酸酶敏感蛋白合成的特性与稳定性
Proc Natl Acad Sci U S A. 1961 Oct 15;47(10):1580-8. doi: 10.1073/pnas.47.10.1580.
2
DEMONSTRATION OF AN ALTERED AMINOACYL RIBONUCLEIC ACID SYNTHETASE IN A MUTANT OF ESCHERICHIA COLI.大肠杆菌突变体中一种改变的氨酰核糖核酸合成酶的证明
J Biol Chem. 1964 Jun;239:1839-43.
3
TUMOR INHIBITORY EFFECT OF L-ASPARAGINASE FROM ESCHERICHIA COLI.大肠杆菌L-天冬酰胺酶的肿瘤抑制作用
Arch Biochem Biophys. 1964 May;105:450-2. doi: 10.1016/0003-9861(64)90032-3.
4
PURIFICATION AND SUBSTRATE SPECIFICITY OF ARGINYL-RIBONUCLEIC ACID SYNTHETASE FROM RAT LIVER.大鼠肝脏精氨酰核糖核酸合成酶的纯化及底物特异性
J Biol Chem. 1964 Apr;239:1102-6.
5
Effect of normal sera of several related rodents on 6C3HED lymphoma in vivo.几种相关啮齿动物的正常血清对6C3HED淋巴瘤的体内作用。
Proc Soc Exp Biol Med. 1963 Jun;113:444-5. doi: 10.3181/00379727-113-28391.
6
Purification and properties of tyrosine-activating enzyme of hog pancreas.猪胰酪氨酸激活酶的纯化及性质
J Biol Chem. 1958 Nov;233(5):1104-8.
7
A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.一种用于光度法测定氨基酸及相关化合物的改良茚三酮试剂。
J Biol Chem. 1954 Dec;211(2):907-13.
8
Alterations in protein and nucleic acid metabolism of lymphoma 6C3HED-og cells in mice given guinea pig serum.给小鼠注射豚鼠血清后淋巴瘤6C3HED-og细胞蛋白质和核酸代谢的变化
J Exp Med. 1966 Jan 1;123(1):55-74. doi: 10.1084/jem.123.1.55.
9
Antilymphoma activity of L-asparaginase in vivo: clearance rates of enzyme preparations from guinea pig serum and yeast in relation to their effect on tumor growth.L-天冬酰胺酶在体内的抗淋巴瘤活性：豚鼠血清和酵母中酶制剂的清除率与其对肿瘤生长的影响
J Natl Cancer Inst. 1965 Dec;35(6):967-74.

Two L-asparaginases from E. coli and their action against tumors.

作者信息

Schwartz J H, Reeves J Y, Broome J D

出版信息

Proc Natl Acad Sci U S A. 1966 Nov;56(5):1516-9. doi: 10.1073/pnas.56.5.1516.

DOI:10.1073/pnas.56.5.1516
PMID:5339624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC220017/
Abstract
摘要