Black P
Neurosurgery. 1979 Oct;5(4):507-18. doi: 10.1227/00006123-197910000-00020.
This paper provides an overview of the current status of the management of cancer pain. The concept of "total care" of the patient with cancer incorporates an effort to eradicate or suppress the underlying malignancy, but when this is no longer feasible emphasis is shifted to symptom control to maximize the quality of remaining life. Even though the malignancy cannot be eradicated, an important first step in pain control is the diagnostic identification of the source of pain because it is preferable to treat the pain specifically rather than symptomatically. Alleviation of the patient's "total agony" requires treatment of the emotional as well as the physical component of pain. In addition, successful management is facilitated by attention to the social needs of both patient and family. Pharmacological therapy is the keystone of pain management; this includes the use of psychotropic agents and narcotic analgesics given orally on a regular schedule to prevent pain, rather than treating the pain after it has appeared. The hospice approach embodies the principles of pharmacological therapy and social, spiritual, and emotional support for the patient and family. These noninvasive methods have been shown to be effective in an increasing proportion of patients with advanced cancer, resulting in a decline in the need for neurosurgical intervention. However, in some patients conservative management fails and neurosurgical intervention should be considered. For those who are candidates for neurosurgical intervention, a wide variety of procedures is available. The selection of specific procedures depends on the source and severity of the pain and on the life expectancy and general condition of the patient.
本文概述了癌症疼痛管理的现状。癌症患者“全面护理”的理念包括努力根除或抑制潜在的恶性肿瘤,但当这不再可行时,重点就转向症状控制,以最大限度地提高剩余生命的质量。即使无法根除恶性肿瘤,疼痛控制的重要第一步也是诊断性地确定疼痛来源,因为特异性治疗疼痛比对症治疗更可取。缓解患者的“全部痛苦”需要治疗疼痛的情感和身体成分。此外,关注患者和家属的社会需求有助于成功管理。药物治疗是疼痛管理的基石;这包括定期口服使用精神药物和麻醉性镇痛药以预防疼痛,而不是在疼痛出现后再进行治疗。临终关怀方法体现了药物治疗以及对患者和家属的社会、精神和情感支持的原则。这些非侵入性方法已被证明对越来越多的晚期癌症患者有效,从而减少了神经外科干预的需求。然而,在一些患者中,保守治疗失败,应考虑神经外科干预。对于那些适合神经外科干预的患者,有多种手术可供选择。具体手术的选择取决于疼痛的来源和严重程度以及患者的预期寿命和一般状况。