Ionescu M I, Wooler G H, Smith D R, Grimshaw V A
Thorax. 1967 Jul;22(4):305-13. doi: 10.1136/thx.22.4.305.
The complications associated with the implantation of prosthetic valves and the experimental attempts to graft the mitral valve are described. Because of the disadvantages connected with the use of artificial valves and as the experimental methods of grafting the mitral valve did not prove satisfactory for clinical use, the authors developed a technique for mitral valve replacement using heterologous aortic valves—reinforced by a semirigid Teflon ring—placed above the mitral annulus inside the atrial cavity. The technique of collecting, preparing, and inserting these grafts is described in detail. Using this method, seven patients with mitral incompetence or mitral disease were operated upon between February and April, 1967. One patient died five weeks after the operation from bacterial endocarditis in a period of severe hospital infection with staphylococcus. The other six patients had a very good clinical result immediately after surgery. At the present time they are symptom-free and have normal heart sounds. Clinical and experimental data are discussed concerning the long-term fate of aortic heterografts in the mitral position.
文中描述了人工瓣膜植入相关的并发症以及二尖瓣移植的实验尝试。由于使用人工瓣膜存在缺点，且二尖瓣移植的实验方法在临床应用中未被证明令人满意，作者开发了一种使用异种主动脉瓣进行二尖瓣置换的技术——通过半刚性聚四氟乙烯环加强——置于心房腔内二尖瓣环上方。详细描述了收集、制备和插入这些移植物的技术。使用这种方法，在1967年2月至4月期间，对7例二尖瓣关闭不全或二尖瓣疾病患者进行了手术。1例患者在术后5周死于细菌性心内膜炎，当时处于严重的医院葡萄球菌感染期。其他6例患者术后立即获得了非常好的临床效果。目前他们无症状，心音正常。文中还讨论了二尖瓣位主动脉异种移植物长期转归的临床和实验数据。
