Bailey B J, Nahum A M
Calif Med. 1966 Oct;105(4):271-5.
To evaluate the effectiveness of Oxyphenbutazone as an anti-inflammatory agent, a double-blind study of Oxyphenbutazone and a placebo in a group of 42 patients who had nasal cosmetic operations involving osteotomy was carried out. The observations included direct objective measurement of the width of the palpebral fissure after operation, grading of the severity of postoperative edema and ecchymosis from photographs, and observations by the patients regarding the clearing of the postoperative discoloration. It appeared from the results of these observations that Oxyphenbutazone is not effective in preventing postoperative edema in such operations or in promoting more rapid resolution of postoperative edema. It did appear to enhance the clearing of postoperative periorbital ecchymosis.
为评估羟基保泰松作为抗炎药的有效性，对42例接受涉及截骨术的鼻部整形手术患者进行了一项羟基保泰松与安慰剂的双盲研究。观察指标包括术后直接客观测量睑裂宽度、根据照片对术后水肿和瘀斑的严重程度进行分级，以及患者对术后色素沉着消退情况的观察。从这些观察结果来看，羟基保泰松在预防此类手术的术后水肿或促进术后水肿更快消退方面并无效果。不过，它似乎确实能促进术后眶周瘀斑的消退。
