Griffies W S, Kennedy K, Gasser C, Fankhauser C, Taylor R
Department of Otolaryngology--Head and Neck Surgery, Naval Hospital, Oakland, CA 94627.
Laryngoscope. 1989 Nov;99(11):1161-4. doi: 10.1288/00005537-198911000-00010.
A prospective double-blind randomized pilot study was performed to test the benefits of steroids versus placebo in controlling edema and ecchymosis in rhinoplasty within the immediate postoperative period. Thirty consecutive patients who underwent rhinoplasty with osteotomies were entered into the study. Sixteen patients received 10 mg of intravenous dexamethasone before the procedure and 14 patients received placebo. All rhinoplasties were performed by residents under the supervision of staff otolaryngologists. A 4-point scale was used to assess the extent of periorbital edema and ecchymosis at 24 hours postoperatively. A one-time bolus of 10 mg of dexamethasone was beneficial in decreasing edema and ecchymosis in rhinoplasty. This benefit was demonstrated statistically (p less than .005). No complications were attributed to the administration of dexamethasone.
进行了一项前瞻性双盲随机试验研究，以测试类固醇与安慰剂在控制鼻整形术后即刻水肿和瘀斑方面的效果。连续30例行截骨鼻整形术的患者纳入研究。16例患者在手术前接受10毫克静脉注射地塞米松，14例患者接受安慰剂。所有鼻整形手术均由住院医师在耳鼻喉科 staff 的监督下进行。采用4分制量表在术后24小时评估眶周水肿和瘀斑的程度。一次性静脉推注10毫克地塞米松有助于减轻鼻整形术中的水肿和瘀斑。这一效果具有统计学意义（p小于0.005）。未发现地塞米松给药引起的并发症。
