Ulmann A, Dard S, Lacour B, Rieu M, Roullet J B, Gueris J, Funck-Brentano J L
Nouv Presse Med. 1979 Nov 12;8(44):3619-22.
Eleven patients with kidney stone disease and idiopathic hypercalciuria (urinary calcium above 4 mg/kg/j), without phosphorus renal leak and 6 control subjects have been put for 3 days on a diet containing 1 g calcium and 1 phosphorus daily (period A), and then for 4 days on a diet containing 1 g calcium, 450 mg phosphorus and 3 g aluminium hydroxyde daily (period B). During period A, no significant difference in blood calcium, phosphorus and magnesium, not in phosphaturia, rate of phosphorus reabsorption (RPR) and ratio maximum RPR/creatinine clearance was found between the two groups. After 2 days on a low phosphate diet (period B) the blood phosphorus decreased significantly in the hypercalciuric patients but not in the control subjects, thus revealing among the forme a latent abnormality in the retention of phosphates. This abnormality could play an important role in the pathogenesis of hypercalciuria.
11例肾结石病伴特发性高钙尿症（尿钙高于4mg/kg/日）且无肾性磷漏的患者以及6名对照受试者，先接受每日含1g钙和1g磷的饮食3天（A期），然后接受每日含1g钙、450mg磷和3g氢氧化铝的饮食4天（B期）。在A期，两组之间的血钙、磷、镁水平，以及磷尿、磷重吸收率（RPR）和最大RPR/肌酐清除率比值均无显著差异。在低磷饮食2天后（B期），高钙尿症患者的血磷显著下降，而对照受试者则无此现象，这表明前者存在潜在的磷酸盐潴留异常。这种异常可能在高钙尿症的发病机制中起重要作用。
