Aubert J, Ulmann A, Lacour B, Bader C, Funck-Brentano J L
Nephrologie. 1980;1(4):159-62.
Changes in phosphatemia and in maximum renal threshold phosphate concentration (TmP/GFR) have been measured before and 45 and 75 min after oral ingestion of 75 g of glucose in 10 hypercalciuric lithiasic patients (HCI), 8 normocalciuric lithiasic patients (NCI) and 7 control subjects. After glucose ingestion, whereas plasma phosphorus decreased in all 3 groups, TmP/GFR decreased significantly in HCI and NCI but not in controls. A slight increase in calcium excretion was noted in the subjects with HCI and NCI after glucose load. Plasma concentration of 1,25(OH)2D was measured in 8 HCI and 7 controls before and after glucose: there was a significant increase in HCI 45 min after glucose and no modification in control subjects. These results show that a glucose load causes a decrease in TmP/GFR in lithiasic subjects. The results demonstrate the existence in lithiasic patients of perturbations of renal handling of phosphates which could, at least in part, be related to glucose metabolism. This trouble could contribute to the elevation of the serum 1,25(OH)2D observed in these patients.
在10名高钙尿性结石患者（HCI）、8名正常钙尿性结石患者（NCI）和7名对照受试者中，在口服75克葡萄糖之前以及之后45分钟和75分钟，测量了血磷水平和最大肾磷阈浓度（TmP/GFR）的变化。摄入葡萄糖后，虽然三组的血浆磷均下降，但HCI组和NCI组的TmP/GFR显著下降，而对照组则未下降。葡萄糖负荷后，HCI组和NCI组受试者的钙排泄略有增加。在8名HCI患者和7名对照受试者中，在葡萄糖摄入前后测量了1,25(OH)2D的血浆浓度：葡萄糖摄入后45分钟，HCI组显著升高，而对照受试者无变化。这些结果表明，葡萄糖负荷会导致结石患者的TmP/GFR降低。结果表明，结石患者存在肾脏对磷酸盐处理的紊乱，这至少部分可能与葡萄糖代谢有关。这种紊乱可能导致这些患者血清1,25(OH)2D升高。
