关于α-脱氢生物素的生物学研究。
Biological studies with alpha-dehydrobiotin.
作者信息
Hanka L J, Reineke L M, Martin D G
出版信息
J Bacteriol. 1969 Oct;100(1):42-6. doi: 10.1128/jb.100.1.42-46.1969.
A growing culture of Streptomyces lydicus converted biotin-(14)C to alpha-dehydrobiotin-(14)C. The conversion was demonstrated by isolating crystalline alpha-dehydrobiotin-(14)C from fermentation liquors supplemented with biotin-(14)C. The addition of pimelic acid-(14)C to the growing culture did not produce any radioactive alpha-dehydrobiotin. alpha-Dehydrobiotin did not substitute for biotin in Lactobacillus plantarum or in Saccharomyces cerevisiae. Antimicrobial activity of alpha-dehydrobiotin was abolished by avidin. alpha-Dehydrobiotin appears to be different from several biotin vitamers described in the literature. It is concluded that alpha-dehydrobiotin is a product of biotin catabolism in S. lydicus.
里氏链霉菌的培养物将生物素 -（14）C 转化为α - 脱氢生物素 -（14）C。通过从添加了生物素 -（14）C 的发酵液中分离出结晶的α - 脱氢生物素 -（14）C 来证明这种转化。向生长的培养物中添加庚二酸 -（14）C 不会产生任何放射性的α - 脱氢生物素。α - 脱氢生物素不能替代植物乳杆菌或酿酒酵母中的生物素。抗生物素蛋白消除了α - 脱氢生物素的抗菌活性。α - 脱氢生物素似乎与文献中描述的几种生物素维生素类似物不同。得出的结论是，α - 脱氢生物素是里氏链霉菌中生物素分解代谢的产物。
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