生物素的两种新型抗代谢物：α-甲基去硫生物素和α-甲基生物素。
Two new antimetabolites of biotin: alpha-methyldethiobiotin and alpha-methylbiotin.
作者信息
Hanka L J, Martin D G, Reineke L M
出版信息
Antimicrob Agents Chemother. 1972 Feb;1(2):135-8. doi: 10.1128/AAC.1.2.135.
Abstract
Two new antimetabolites of biotin were isolated from culture filtrates of Streptomyces lydicus: beta-methyldethiobiotin and beta-methylbiotin. (14)C-biotin or (14)C-pimelic acid was not incorporated into either of these antimetabolites by the growing culture. Neither of the compounds could substitute for the biotin requirement in Saccharomyces cerevisiae. Both compounds had a strong and rather specific antimicrobial effect against mycobacteria. Their antimicrobial activities were reversed by biotin. Both compounds had an affinity for avidin.
摘要
从利迪链霉菌的培养滤液中分离出两种新的生物素抗代谢物
β-甲基去硫生物素和β-甲基生物素。生长中的培养物未将¹⁴C-生物素或¹⁴C-庚二酸掺入这些抗代谢物中的任何一种。这两种化合物都不能替代酿酒酵母对生物素的需求。两种化合物对分枝杆菌都有强烈且相当特异的抗菌作用。它们的抗菌活性可被生物素逆转。两种化合物都对抗生物素蛋白有亲和力。
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本文引用的文献
1
The biosynthesis of biotin in growing yeast cells: The formation of biotin from an early intermediate.在生长酵母细胞中生物素的生物合成：从早期中间产物形成生物素。
Biochem J. 1966 Dec;101(3):598-600. doi: 10.1042/bj1010598.
2
HEAT STABILITY OF AVIDIN AND AVIDIN-BIOTIN COMPLEX AND INFLUENCE OF IONIC STRENGTH ON AFFINITY OF AVIDIN FOR BIOTIN.抗生物素蛋白及抗生物素蛋白-生物素复合物的热稳定性以及离子强度对抗生物素蛋白与生物素亲和力的影响
Proc Soc Exp Biol Med. 1964 Nov;117:341-4. doi: 10.3181/00379727-117-29576.
3
Naturally occurring antimetabolite antibiotic related to biotin.与生物素相关的天然存在的抗代谢物抗生素。
Science. 1966 Dec 30;154(3757):1667-8. doi: 10.1126/science.154.3757.1667.
4
Biological studies with alpha-dehydrobiotin.关于α-脱氢生物素的生物学研究。
J Bacteriol. 1969 Oct;100(1):42-6. doi: 10.1128/jb.100.1.42-46.1969.
5
Bacterial degradation of biotin. Catabolism of 14C-biotin and its sulfoxides.生物素的细菌降解。14C-生物素及其亚砜的分解代谢。
J Biol Chem. 1966 Oct 25;241(20):4717-21.
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