生物素的两种新型抗代谢物：α-甲基去硫生物素和α-甲基生物素。
Two new antimetabolites of biotin: alpha-methyldethiobiotin and alpha-methylbiotin.
作者信息
Hanka L J, Martin D G, Reineke L M
出版信息
Antimicrob Agents Chemother. 1972 Feb;1(2):135-8. doi: 10.1128/AAC.1.2.135.
Abstract
Two new antimetabolites of biotin were isolated from culture filtrates of Streptomyces lydicus: beta-methyldethiobiotin and beta-methylbiotin. (14)C-biotin or (14)C-pimelic acid was not incorporated into either of these antimetabolites by the growing culture. Neither of the compounds could substitute for the biotin requirement in Saccharomyces cerevisiae. Both compounds had a strong and rather specific antimicrobial effect against mycobacteria. Their antimicrobial activities were reversed by biotin. Both compounds had an affinity for avidin.
摘要
从利迪链霉菌的培养滤液中分离出两种新的生物素抗代谢物
β-甲基去硫生物素和β-甲基生物素。生长中的培养物未将¹⁴C-生物素或¹⁴C-庚二酸掺入这些抗代谢物中的任何一种。这两种化合物都不能替代酿酒酵母对生物素的需求。两种化合物对分枝杆菌都有强烈且相当特异的抗菌作用。它们的抗菌活性可被生物素逆转。两种化合物都对抗生物素蛋白有亲和力。
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