Schwartz J, Elizan T S
Ann Neurol. 1979 Sep;6(3):261-3. doi: 10.1002/ana.410060314.
Virological studies were performed on brain material from 9 patients with idiopathic Parkinson disease and 3 matched controls. Electron microscopy and indirect immunofluorescent study were carried out directly on autopsy material from substantia nigra, caudate nucleus, and hypothalamus and on primary tissue culture explants of these brain areas grown alone or in cocultivation with virus-susceptible indicator cell lines. All studies were negative for the presence of viral particles, viral inclusions, or cellular changes suggestive of virus infection. All materials were negative for antigens of herpes simplex type 1, influenza A/NWS, and measles (Edmonston strain) viruses. Within the limits of these tehcniques, there is no evidence at this time that viruses are an important etiological agent in idiopathic Parkinson disease.
对9例特发性帕金森病患者的脑材料和3例匹配对照进行了病毒学研究。直接对来自黑质、尾状核和下丘脑的尸检材料以及这些脑区单独培养或与病毒易感指示细胞系共培养的原代组织培养外植体进行了电子显微镜检查和间接免疫荧光研究。所有研究均未发现病毒颗粒、病毒包涵体或提示病毒感染的细胞变化。所有材料均未检测到单纯疱疹病毒1型、甲型流感病毒（A/NWS）和麻疹病毒（埃德蒙斯顿株）的抗原。在这些技术的检测范围内，目前没有证据表明病毒是特发性帕金森病的重要病因。
