Wetmur J G, Schwartz J, Elizan T S
Arch Neurol. 1979 Aug;36(8):462-4. doi: 10.1001/archneur.1979.00500440032004.
Reassociation kinetics analyses with radioiodinated herpes simplex type 1 DNA and influenza A/NWS RNA were performed in the presence of tissue nucleic acids from defined loci of the brains of nine patients with idiopathic Parkinson's disease, one normal control brain, and the brains of uninfected mice or mice infected with either herpes simplex type 1 virus or influenza A/NWS virus. Herpes simplex type 1 DNA was detected by an increased reassociation rate in the herpes simplex type 1 virus-infected mouse brains. Influenza A/NWS RNA was detected by reassociation in the influenza A/NWS virus-infected mouse brains. Experimental limits for the detection of homologous nucleic acids are given for each separate experiment with human or mouse tissue. Within these detection limits, nucleic acids complementary to herpes simplex type 1 DNA or influenza A/NWS RNA were not detected in any of the brains of patients with idiopathic Parkinson's disease.
在存在来自9例特发性帕金森病患者大脑特定区域、1个正常对照大脑以及未感染小鼠或感染单纯疱疹病毒1型或甲型流感病毒NWS株的小鼠大脑的组织核酸的情况下，对放射性碘化的单纯疱疹病毒1型DNA和甲型流感病毒NWS株RNA进行了复性动力学分析。在感染单纯疱疹病毒1型的小鼠大脑中，通过复性率增加检测到单纯疱疹病毒1型DNA。在感染甲型流感病毒NWS株的小鼠大脑中，通过复性检测到甲型流感病毒NWS株RNA。针对每次用人或小鼠组织进行的单独实验，给出了检测同源核酸的实验限度。在这些检测限度内，在任何特发性帕金森病患者的大脑中均未检测到与单纯疱疹病毒1型DNA或甲型流感病毒NWS株RNA互补的核酸。
