佛波醇12-肉豆蔻酸酯13-乙酸酯与皮质醇相互作用对大鼠类固醇结合能力的影响。
Effects of phorbol 12-myristate 13-acetate and cortisol interaction on steroid-binding capacity in the rat.
作者信息
Janssens J P, de Loecker W
出版信息
Biochem J. 1979 Nov 15;184(2):361-5. doi: 10.1042/bj1840361.
Abstract
The specificity of the cortisol-receptor protein is examined in plasma and liver cytosol of rats. Phorbol 12-myristate 13-acetate does not inhibit the binding of cortisol to transcortin, nor does it affect the binding capacity of dexamethasone to the intracellular glucocorticoid receptor, but, by interacting with the cortisol molecule, it interferes with hormone-mediated processes in the cell.
摘要
在大鼠的血浆和肝细胞溶胶中检测了皮质醇受体蛋白的特异性。佛波酯不抑制皮质醇与皮质素转运蛋白的结合，也不影响地塞米松与细胞内糖皮质激素受体的结合能力，但通过与皮质醇分子相互作用，它会干扰细胞内激素介导的过程。
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Stimulation of the phosphorylation of mouse epidermal histones by tumor-promoting agents.肿瘤促进剂对小鼠表皮组蛋白磷酸化的刺激作用。
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Phorbolesters--the irritants and cocarcinogens of Croton Tiglium L.佛波酯——巴豆的刺激物和促癌物
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Ultrastructural changes in the epidermis of mice induced by methylcholanthrene, croton oil and phorbol.
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Nonspecific inhibition of DNA repair by promoting and nonpromoting phorbol esters.通过促癌和非促癌佛波酯对DNA修复进行非特异性抑制
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