雌性大鼠下丘脑雌激素受体含量的发育变化
Developmental changes in the content of oestrogen receptors in the hypothalamus of the female rat.
作者信息
White J O, Hall C, Lim L
出版信息
Biochem J. 1979 Nov 15;184(2):465-8. doi: 10.1042/bj1840465.
Abstract
Hypothalamic cytosol and nuclear oestrogen receptors are present at birth. A 2-fold increase in cytoplasmic receptor content occurs by the second week, whereas the first significant and equivalent increase in nuclear receptor occurs in the fourth week. The latter reflects reported increases in oestradiol availability thought to lead to complete feminine sexual differentiation. The presence of nuclear receptors in the newborn suggests a requirement for oestrogenic stimulation in early development.
摘要
下丘脑胞质溶胶和核雌激素受体在出生时就已存在。到第二周时，细胞质受体含量增加了两倍，而核受体的首次显著且等量增加发生在第四周。后者反映了据报道雌二醇可用性的增加，这被认为会导致完全的女性性别分化。新生儿中核受体的存在表明早期发育中需要雌激素刺激。
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2
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Steroids. 1971 Dec;18(6):767-88. doi: 10.1016/0039-128x(71)90035-3.
3
Conversion of androstenedione to estrone by neural tissues from fetal and neonatal rats.
Endocrinology. 1974 Jan;94(1):117-21. doi: 10.1210/endo-94-1-117.
4
Ontogeny of estradiol-binding sites in rat brain. II. Characteristics of a neonatal binding macromolecule.
Endocrinology. 1973 Nov;93(5):1129-39. doi: 10.1210/endo-93-5-1129.
5
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Endocrinology. 1973 Nov;93(5):1119-28. doi: 10.1210/endo-93-5-1119.
6
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Nature. 1974 Nov 15;252(5480):259-60. doi: 10.1038/252259a0.
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8
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