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1
Developmental changes in the content of oestrogen receptors in the hypothalamus of the female rat.雌性大鼠下丘脑雌激素受体含量的发育变化
Biochem J. 1979 Nov 15;184(2):465-8. doi: 10.1042/bj1840465.
2
Unoccupied nuclear oestrogen receptors in the female rat hypothalamus. Increases on oestrogen administration.雌性大鼠下丘脑未占据的核雌激素受体。雌激素给药后增加。
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Intracellular relationships of the oestrogen receptor in the rat uterus and hypothalamus during the oestrous cycle.发情周期中大鼠子宫和下丘脑雌激素受体的细胞内关系
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The nuclear oestrogen receptor in the female rat. Effects of oestradiol administration during the oestrous cycle on the uterus and contrasting effects of progesterone on the uterus and hypothalamus.雌性大鼠的核雌激素受体。发情周期中雌二醇给药对子宫的影响以及孕酮对子宫和下丘脑的不同影响。
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The oestrogen receptor of the female rate hypothalamus: relationship between nuclear content and oligothymidylate-cellulose binding of cytosol receptor [proceedings].雌性大鼠下丘脑的雌激素受体：细胞核含量与胞质溶胶受体的寡聚胸苷酸 - 纤维素结合之间的关系[会议论文集]
Biochem Soc Trans. 1977;5(5):1558-60. doi: 10.1042/bst0051558.
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The unoccupied nuclear oestradiol receptor in the rat uterus and hypothalamus during the oestrous cycle.大鼠发情周期中子宫和下丘脑未被占据的核雌激素受体。
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The oestrogen receptor in the rat hypothalamus: nuclear responses to oestrogen administration [proceedings].大鼠下丘脑雌激素受体：雌激素给药后的核反应[会议论文集]
Biochem Soc Trans. 1978;6(6):1310-2. doi: 10.1042/bst0061310.
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Oestradiol, sexual receptivity and cytosol progestin receptors in rat hypothalamus.
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Uterine oestrogen-receptor binding to oligo(dT)-cellulose. An inhibitor from hypothalamic cytosol.子宫雌激素受体与寡聚（dT）-纤维素的结合。一种来自下丘脑胞质溶胶的抑制剂。
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Nucleo-cytoplasmic relationships of oestrogen receptors in rat liver during the oestrous cycle and in response to administered natural and synthetic oestrogen.大鼠肝脏中雌激素受体在发情周期以及对天然和合成雌激素给药反应中的核质关系
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引用本文的文献

1
Sexually dimorphic expression of hypothalamic estrogen receptors α and β and Kiss1 in neonatal male and female rats.新生雄性和雌性大鼠下丘脑雌激素受体 α 和 β 及 Kiss1 的性别二态性表达。
J Comp Neurol. 2011 Oct 15;519(15):2954-77. doi: 10.1002/cne.22648.

本文引用的文献

1
Induction and facilitation of female mating behavior in rats treated neonatally with low doses of testosterone propionate.新生期用低剂量丙酸睾酮处理的大鼠中雌性交配行为的诱导与促进。
Endocrinology. 1969 Jun;84(6):1430-8. doi: 10.1210/endo-84-6-1430.
2
Rat estradiol binding plasma protein (EBP).大鼠雌二醇结合血浆蛋白（EBP）。
Steroids. 1971 Dec;18(6):767-88. doi: 10.1016/0039-128x(71)90035-3.
3
Conversion of androstenedione to estrone by neural tissues from fetal and neonatal rats.
Endocrinology. 1974 Jan;94(1):117-21. doi: 10.1210/endo-94-1-117.
4
Ontogeny of estradiol-binding sites in rat brain. II. Characteristics of a neonatal binding macromolecule.
Endocrinology. 1973 Nov;93(5):1129-39. doi: 10.1210/endo-93-5-1129.
5
Ontogeny of estradiol-binding sites in rat brain. I. Appearance of presumptive adult receptors in cytosol and nuclei.大鼠脑中雌二醇结合位点的个体发生。I. 胞浆和细胞核中假定的成年受体的出现。
Endocrinology. 1973 Nov;93(5):1119-28. doi: 10.1210/endo-93-5-1119.
6
A receptor mediating sexual differentiation?一种介导性别分化的受体？
Nature. 1974 Nov 15;252(5480):259-60. doi: 10.1038/252259a0.
7
Nuclear receptor estrogen complex: accumulation, retention and localization in the hypothalamus and pituitary.核受体雌激素复合物：在下丘脑和垂体中的积累、滞留及定位
Endocrinology. 1973 Sep;93(3):711-7. doi: 10.1210/endo-93-3-711.
8
Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro: implications for sexual differentiation.
Brain Res. 1976 Apr 23;106(2):407-12. doi: 10.1016/0006-8993(76)91038-6.
9
The selective isolation of the uterine oestradiol-receptor complex by binding to oligo(dT)-cellulose. The mediation of an essential activator in the transformation of cytosol receptor.通过与寡聚（dT）-纤维素结合来选择性分离子宫雌二醇受体复合物。一种必需激活剂在胞质溶胶受体转化中的介导作用。
Biochem J. 1976 Nov 15;160(2):271-80. doi: 10.1042/bj1600271.
10
Nuclear binding of the oestrogen receptor of neonatal rat brain after injection of oestrogens and androgens; localization and sex differences.
Brain Res. 1977 Jan 7;119(2):375-88. doi: 10.1016/0006-8993(77)90317-1.

雌性大鼠下丘脑雌激素受体含量的发育变化

Developmental changes in the content of oestrogen receptors in the hypothalamus of the female rat.

作者信息

White J O, Hall C, Lim L

出版信息

Biochem J. 1979 Nov 15;184(2):465-8. doi: 10.1042/bj1840465.

DOI:10.1042/bj1840465
PMID:534541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161784/
Abstract

Hypothalamic cytosol and nuclear oestrogen receptors are present at birth. A 2-fold increase in cytoplasmic receptor content occurs by the second week, whereas the first significant and equivalent increase in nuclear receptor occurs in the fourth week. The latter reflects reported increases in oestradiol availability thought to lead to complete feminine sexual differentiation. The presence of nuclear receptors in the newborn suggests a requirement for oestrogenic stimulation in early development.

摘要

下丘脑胞质溶胶和核雌激素受体在出生时就已存在。到第二周时，细胞质受体含量增加了两倍，而核受体的首次显著且等量增加发生在第四周。后者反映了据报道雌二醇可用性的增加，这被认为会导致完全的女性性别分化。新生儿中核受体的存在表明早期发育中需要雌激素刺激。