雌性大鼠下丘脑未占据的核雌激素受体。雌激素给药后增加。
Unoccupied nuclear oestrogen receptors in the female rat hypothalamus. Increases on oestrogen administration.
作者信息
White J O, Lim L
出版信息
Biochem J. 1980 Sep 15;190(3):833-7. doi: 10.1042/bj1900833.
Abstract
A major proportion of the hypothalamic nuclear oestrogen receptors were available for complexing with radioactive oestradiol in vitro at 4 degrees C and were apparently unoccupied . At 6 h after oestradiol administration the content of unoccupied nuclear receptors had increased 2.5-fold and represented 71% of the total nuclear receptor content. These results suggest that unoccupied receptors may be active elements in the 'long-term' receptor population of the hypothalamus. Androgenized females had lower contents of these receptors.
摘要
下丘脑核雌激素受体的很大一部分在4℃下可在体外与放射性雌二醇结合，且显然未被占据。给予雌二醇后6小时，未被占据的核受体含量增加了2.5倍，占核受体总含量的71%。这些结果表明，未被占据的受体可能是下丘脑“长期”受体群体中的活性成分。雄激素化的雌性动物这些受体的含量较低。
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