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1
Unoccupied nuclear oestrogen receptors in the female rat hypothalamus. Increases on oestrogen administration.雌性大鼠下丘脑未占据的核雌激素受体。雌激素给药后增加。
Biochem J. 1980 Sep 15;190(3):833-7. doi: 10.1042/bj1900833.
2
The unoccupied nuclear oestradiol receptor in the rat uterus and hypothalamus during the oestrous cycle.大鼠发情周期中子宫和下丘脑未被占据的核雌激素受体。
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3
The nuclear oestrogen receptor in the female rat. Effects of oestradiol administration during the oestrous cycle on the uterus and contrasting effects of progesterone on the uterus and hypothalamus.雌性大鼠的核雌激素受体。发情周期中雌二醇给药对子宫的影响以及孕酮对子宫和下丘脑的不同影响。
Biochem J. 1981 Aug 15;198(2):385-9. doi: 10.1042/bj1980385.
4
The oestrogen receptor in the rat hypothalamus: nuclear responses to oestrogen administration [proceedings].大鼠下丘脑雌激素受体：雌激素给药后的核反应[会议论文集]
Biochem Soc Trans. 1978;6(6):1310-2. doi: 10.1042/bst0061310.
5
Developmental changes in the content of oestrogen receptors in the hypothalamus of the female rat.雌性大鼠下丘脑雌激素受体含量的发育变化
Biochem J. 1979 Nov 15;184(2):465-8. doi: 10.1042/bj1840465.
6
Alterations induced by clomiphene in the concentrations of oestrogen receptors in the uterus, pituitary gland and hypothalamus of female rats.克罗米芬对雌性大鼠子宫、垂体和下丘脑雌激素受体浓度的影响。
J Endocrinol. 1980 Dec;87(3):383-92. doi: 10.1677/joe.0.0870383.
7
Oestrogen receptors in cell nuclei of the hypothalamus-preoptic area-amygdala following an injection of oestradiol or the antioestrogen CI-628.
J Endocrinol. 1979 Dec;83(3):285-93. doi: 10.1677/joe.0.0830285.
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Nucleo-cytoplasmic relationships of oestrogen receptors in rat liver during the oestrous cycle and in response to administered natural and synthetic oestrogen.大鼠肝脏中雌激素受体在发情周期以及对天然和合成雌激素给药反应中的核质关系
Biochem J. 1980 Jul 15;190(1):17-25. doi: 10.1042/bj1900017.
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Evidence for the origin of the unoccupied oestrogen receptor in nuclei of a human breast-cancer cell line (MCF-7).人乳腺癌细胞系（MCF-7）细胞核中未占据雌激素受体起源的证据。
Biochem J. 1982 Mar 15;202(3):687-91. doi: 10.1042/bj2020687.
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Unoccupied binding sites for oestrogen in nuclei of a breast tumour cell line (MCF-7).一种乳腺肿瘤细胞系（MCF-7）细胞核中未被占据的雌激素结合位点。
Biochem J. 1981 Dec 15;200(3):515-20. doi: 10.1042/bj2000515.

引用本文的文献

1
The relationship of the oestrogen and progestin receptors in the abnormal uterus of the adult anovulatory rat. Effects of neonatal treatment with testosterone propionate or clomiphene citrate.成年无排卵大鼠异常子宫中雌激素和孕激素受体的关系。丙酸睾酮或枸橼酸氯米芬新生儿期治疗的影响。
Biochem J. 1981 May 15;196(2):557-65. doi: 10.1042/bj1960557.
2
The unoccupied nuclear oestradiol receptor in the rat uterus and hypothalamus during the oestrous cycle.大鼠发情周期中子宫和下丘脑未被占据的核雌激素受体。
Biochem J. 1981 Mar 15;194(3):667-71. doi: 10.1042/bj1940667.
3
Progesterone therapy results in partial reversibility of uterine abnormalities of the adult anovulatory rat.孕酮治疗可使成年无排卵大鼠的子宫异常部分恢复正常。
Biochem J. 1982 Feb 15;202(2):535-41. doi: 10.1042/bj2020535.

本文引用的文献

1
Unoccupied nuclear oestradiol-receptor sites in normal human endometrium.正常人类子宫内膜中未被占据的核雌激素受体位点。
Biochem J. 1980 Mar 1;185(3):733-8. doi: 10.1042/bj1850733.
2
Isolation and fractionation of rat brain nuclei.大鼠脑细胞核的分离与分级分离
J Cell Biol. 1966 Aug;30(2):405-15. doi: 10.1083/jcb.30.2.405.
3
Newly synthesized RNA in nuclei isolated from nerve and glial cells.从神经细胞和神经胶质细胞中分离出的细胞核内新合成的RNA。
J Neurochem. 1970 Jul;17(7):845-52. doi: 10.1111/j.1471-4159.1970.tb02238.x.
4
Oestrogen and nuclear binding sites. Determination of specific sites by ( 3 H)oestradiol exchange.雌激素与核结合位点。通过（³H）雌二醇交换法测定特异性位点。
Biochem J. 1972 Feb;126(3):561-7. doi: 10.1042/bj1260561.
5
An improved method for the study of high-affinity steroid binding:-oestradiol binding in brain and pituitary.一种用于研究高亲和力类固醇结合的改进方法：大脑和垂体中的雌二醇结合。
Steroids. 1974 Jun;23(6):773-92. doi: 10.1016/0039-128x(74)90053-1.
6
Nuclear receptor-estrogen complexes of rat uteri: concentration-time-response parameters.大鼠子宫的核受体-雌激素复合物：浓度-时间-反应参数
Adv Exp Med Biol. 1973;36(0):15-59. doi: 10.1007/978-1-4684-3237-4_2.
7
Nuclear receptor estrogen complex: accumulation, retention and localization in the hypothalamus and pituitary.核受体雌激素复合物：在下丘脑和垂体中的积累、滞留及定位
Endocrinology. 1973 Sep;93(3):711-7. doi: 10.1210/endo-93-3-711.
8
The selective isolation of the uterine oestradiol-receptor complex by binding to oligo(dT)-cellulose. The mediation of an essential activator in the transformation of cytosol receptor.通过与寡聚（dT）-纤维素结合来选择性分离子宫雌二醇受体复合物。一种必需激活剂在胞质溶胶受体转化中的介导作用。
Biochem J. 1976 Nov 15;160(2):271-80. doi: 10.1042/bj1600271.
9
Estrogen receptor. Unoccupied sites in nuclei of a breast tumor cell line.雌激素受体。乳腺肿瘤细胞系细胞核中的未占据位点。
J Biol Chem. 1977 Jun 10;252(11):3703-8.
10
The oestrogen receptor in the rat hypothalamus: nuclear responses to oestrogen administration [proceedings].大鼠下丘脑雌激素受体：雌激素给药后的核反应[会议论文集]
Biochem Soc Trans. 1978;6(6):1310-2. doi: 10.1042/bst0061310.

雌性大鼠下丘脑未占据的核雌激素受体。雌激素给药后增加。

Unoccupied nuclear oestrogen receptors in the female rat hypothalamus. Increases on oestrogen administration.

作者信息

White J O, Lim L

出版信息

Biochem J. 1980 Sep 15;190(3):833-7. doi: 10.1042/bj1900833.

DOI:10.1042/bj1900833
PMID:7470083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1162165/
Abstract

A major proportion of the hypothalamic nuclear oestrogen receptors were available for complexing with radioactive oestradiol in vitro at 4 degrees C and were apparently unoccupied . At 6 h after oestradiol administration the content of unoccupied nuclear receptors had increased 2.5-fold and represented 71% of the total nuclear receptor content. These results suggest that unoccupied receptors may be active elements in the 'long-term' receptor population of the hypothalamus. Androgenized females had lower contents of these receptors.

摘要

下丘脑核雌激素受体的很大一部分在4℃下可在体外与放射性雌二醇结合，且显然未被占据。给予雌二醇后6小时，未被占据的核受体含量增加了2.5倍，占核受体总含量的71%。这些结果表明，未被占据的受体可能是下丘脑“长期”受体群体中的活性成分。雄激素化的雌性动物这些受体的含量较低。