Overgaard J, Nielsen O S, Overgaard M, Steenholdt S, Jakobsen A, Sell A
Acta Radiol Oncol Radiat Phys Biol. 1979;18(4):305-12. doi: 10.3109/02841867909128216.
The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L1A2 tumour cells in vitro, jejunal crypt cells and C3H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.
对具有超氧化物歧化酶活性的金属蛋白——奥古蛋白的潜在辐射防护作用，在体外L1A2肿瘤细胞、空肠隐窝细胞以及体内C3H小鼠乳腺癌模型中进行了研究。与单独照射的效果相比，无论是在照射前2小时还是照射后30分钟给予奥古蛋白，均未观察到其有任何影响。因此，得出结论：奥古蛋白不会影响哺乳动物细胞在空气中的初始辐射反应。
