Cividalli A, Adami M, De Tomasi F, Palmisano L, Pardini M C, Spanò M, Mauro F
Acta Radiol Oncol. 1985 May-Jun;24(3):273-7. doi: 10.3109/02841868509134400.
The effects of Orgotein (a superoxide dismutase) on the radiation response of normal and malignant murine tissue in vivo were evaluated. The observations were made on the mouse hind leg bearing, in some cases, an adenocarcinoma. The following irradiation protocols were tested: 1) single dose (e.g., 35 and 53 Gy), 2) conventional fractionation (3 Gy/day, 5 days a week) and 3) multiple fractions per day (2 X 3 Gy/day, 3 h fractionation interval, 5 days a week). Radiation was either delivered alone or preceded by a subcutaneous injection of 20, 100 or 400 mg/kg Orgotein administered 1 or 2 h before the beginning of irradiation. No effects of Orgotein on tumor radiation response were detected. A protective effect on normal tissue was observed when radiation was delivered according to aggressive protocols and a relatively high dosage of Orgotein was administered. Furthermore, an accelerated trend of recovery of normal tissue was observed.
评估了奥谷蛋白（一种超氧化物歧化酶）对正常和恶性小鼠体内组织辐射反应的影响。观察对象为部分情况下患有腺癌的小鼠后腿。测试了以下照射方案：1）单次剂量（例如，35和53戈瑞），2）常规分割（3戈瑞/天，每周5天）和3）每天多次分割（2×3戈瑞/天，分割间隔3小时，每周5天）。辐射要么单独进行，要么在开始照射前1或2小时皮下注射20、100或400毫克/千克奥谷蛋白。未检测到奥谷蛋白对肿瘤辐射反应的影响。当按照激进方案进行辐射并给予相对高剂量的奥谷蛋白时，观察到对正常组织有保护作用。此外，还观察到正常组织恢复的加速趋势。
