Ayres S, Mihan R
Calif Med. 1969 Aug;111(2):87-91.
A clinical investigation into the therapeutic value of vitamin E (tocopherol) in certain dermatological conditions of obscure etiology led to the incidental observation that this compound produced beneficial effects in some of the patients who were suffering from frequent and severe nocturnal leg cramps. Nearly all of the patients with leg cramps received prompt and gratifying relief from their symptoms while taking vitamin E in the form of d, alpha-tocopheryl acetate, 100 I.U. three times a day before meals. The group included 24 private patients with leg cramps and two with the "restless legs" syndrome, probably a related condition. One of the patients with leg and foot cramps also had severe nocturnal rectal cramps which were also relieved. Nocturnal leg cramps constitute a relatively common complaint in the general practice of medicine and may be very distressing to the patient. Not only is the cause obscure and the treatment relatively unsatisfactory, but even its proper medical name, systremma (anything twisted up together), is unknown to most physicians.
一项关于维生素E（生育酚）在某些病因不明的皮肤病治疗价值的临床研究，意外观察到该化合物对一些患有频繁且严重夜间腿部痉挛的患者产生了有益效果。几乎所有腿部痉挛患者在服用d-α生育酚醋酸酯形式的维生素E（每日三次，每次100国际单位，饭前服用）后，症状都迅速得到了令人满意的缓解。该组包括24名患有腿部痉挛的门诊患者和两名患有“不宁腿”综合征（可能是相关病症）的患者。一名患有腿部和脚部痉挛的患者还伴有严重的夜间直肠痉挛，这些痉挛也得到了缓解。夜间腿部痉挛在普通医学实践中是一种相对常见的病症，可能会给患者带来极大痛苦。不仅其病因不明且治疗效果相对不理想，而且大多数医生甚至都不知道它恰当的医学名称——肌束震颤（任何扭绞在一起的东西）。
