多巴胺输注时的肺循环和体循环反应。

The pulmonary and systemic circulatory response to dopamine infusion.

Harrison D C, Pirages S, Robison S C, Wintroub B U

Br J Pharmacol. 1969 Nov;37(3):618-26. doi: 10.1111/j.1476-5381.1969.tb08500.x.

Abstract

The pulmonary and systemic circulatory responses to dopamine infused at 8, 15, 25 and 30 mug/kg per min were studied in eight mongrel dogs.2. Mean pulmonary artery pressure, mean left atrial pressure, mean aortic pressure, mean aortic flow and the electrocardiogram were monitored in openchest preparations. Pulmonary vascular resistance, systemic vascular resistance and stroke volume were calculated.3. Significant increases in mean pulmonary and aortic pressures were noted at dopamine infusions of 25 and 30 mug/kg per min. The left atrial pressure fell significantly at 15 mug/kg per min and rose significantly at 30 mug/kg per min. Mean aortic flow increased at all four doses, while heart rate showed no change. Pulmonary vascular resistance did not change significantly at any dose level, but systemic vascular resistance fell slightly at 8 and 15 mug/kg per min and rose significantly at 30 mug/kg per min. Stroke volume was significantly elevated at infusions of 25 and 30 mug/kg per min.4. The systemic circulatory response to dopamine is similar to that described by previous investigators.5. The increased pulmonary pressures without change in resistance suggest a dopamine-induced increase in smooth muscle tension in the pulmonary vasculature.

摘要

对8只杂种犬研究了以每分钟8、15、25和30微克/千克的剂量输注多巴胺时的肺循环和体循环反应。
在开胸实验准备中监测平均肺动脉压、平均左心房压、平均主动脉压、平均主动脉血流量和心电图。计算肺血管阻力、体血管阻力和每搏量。
在多巴胺输注速度为每分钟25和30微克/千克时，平均肺动脉压和主动脉压显著升高。左心房压在每分钟15微克/千克时显著下降，在每分钟30微克/千克时显著上升。所有四个剂量下平均主动脉血流量均增加，而心率无变化。在任何剂量水平下肺血管阻力均无显著变化，但在每分钟8和15微克/千克时体血管阻力略有下降，在每分钟30微克/千克时显著上升。在输注速度为每分钟25和30微克/千克时每搏量显著升高。
多巴胺引起的体循环反应与先前研究者所描述的相似。
肺压升高而阻力不变提示多巴胺引起肺血管平滑肌张力增加。