常规血清三碘甲状腺原氨酸测定在甲状腺毒症诊断中的价值。

Value of routine serum-triiodothyronine estimation in diagnosis of thyrotoxicosis.

作者信息

Shalet S M, Beardwell C G, Lamb A M, Gowland E

出版信息

Lancet. 1975 Nov 22;2(7943):1008-10. doi: 10.1016/s0140-6736(75)90293-7.

Abstract

Thyroid-stimulating hormone (T.S.H.), triiodothyronine (T3), and thyroxine (T4) concentrations were estimated on 432 blood specimens from patients with a provisional diagnosis of thyrotoxicosis. 59 patients had a raised serum T3 concentration with T.S.H. and T4 levels in the normal range. Further information was obtained in 41 of these patients, and T3 toxicosis was diagnosed in 17 cases, thus providing a projected total of 24 patients with T3 toxicosis. In addition, there were 56 patients, with more common biochemical features of thyrotoxicosis, having both a raised serum T3 and T4 concentration. Therefore 30% of the patients considered thyrotoxic in this retrospective survey were only diagnosed with the aid of a serum-T3 estimation.

摘要

对初步诊断为甲状腺毒症的患者的432份血液样本进行了促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）浓度的测定。59例患者血清T3浓度升高，TSH和T4水平在正常范围内。在其中41例患者中获得了进一步信息，17例诊断为T3毒症，因此预计共有24例T3毒症患者。此外，有56例患者具有更常见的甲状腺毒症生化特征，血清T3和T4浓度均升高。因此，在这项回顾性调查中，30%被认为患有甲状腺毒症的患者仅借助血清T3测定得以确诊。