Oka T, Schimke R T
J Cell Biol. 1969 Oct;43(1):123-37. doi: 10.1083/jcb.43.1.123.
The effects of estrogen and progesterone on the function of chick oviduct tubular gland cells have been studied. Such function, as measured by the increase in specific cell products such as lysozyme and ovalbumin, requires the continuous presence of estrogen or progesterone. Withdrawal of hormone results in a rapid cessation of function and an involution of the oviduct accompanied by rapid decreases in total weight, lysozyme, and RNA. During such involution, tubular gland cells per se persist, as evidenced by a lack of comparable decrease in total DNA content and by histological demonstration of tubular gland cells. When estrogen administration is reinstituted, preexisting tubular gland cells rapidly synthesize ovalbumin and lysozyme without requiring new DNA synthesis. Administration of progesterone also stimulates the function of such cells. Furthermore, the effects of estrogen and progesterone are synergistic on the synthesis of lysozyme and ovalbumin, whereas progesterone antagonizes the estrogen-evoked formation of tubular gland cells. It is suggested that such complex interactions of estrogen and progesterone on oviduct development and function result from differences in responsiveness of the various cell types present in the tissue.
雌激素和孕酮对鸡输卵管管状腺细胞功能的影响已得到研究。这种功能，通过诸如溶菌酶和卵清蛋白等特定细胞产物的增加来衡量，需要持续存在雌激素或孕酮。激素撤除会导致功能迅速停止，输卵管退化，同时总重量、溶菌酶和RNA迅速减少。在这种退化过程中，管状腺细胞本身持续存在，这可通过总DNA含量缺乏可比的减少以及管状腺细胞的组织学证明来证实。当重新给予雌激素时，先前存在的管状腺细胞迅速合成卵清蛋白和溶菌酶，而无需新的DNA合成。给予孕酮也会刺激这些细胞的功能。此外，雌激素和孕酮在溶菌酶和卵清蛋白合成上具有协同作用，而孕酮则拮抗雌激素诱导的管状腺细胞形成。有人认为，雌激素和孕酮对输卵管发育和功能的这种复杂相互作用是由于组织中存在的各种细胞类型反应性的差异所致。
