Azmitia E C, McEwen B S
Science. 1969 Dec 5;166(3910):1274-6. doi: 10.1126/science.166.3910.1274.
The tryptophan hydroxylase activity in the rat midbrain decreases after adrenalectomy and is restored by treatment with corticosterone. Cycloheximide, adminiistered intracisternally, prevents the restoration of the enzyme activity by corticosterone. Cycloheximide administration to adrenalectomized rats resutlts in a further decrease in the enzyme activity. an indication that the enzyme has a rapid turnover even in the absence of corticosterone.
大鼠中脑的色氨酸羟化酶活性在肾上腺切除术后降低，并通过皮质酮治疗得以恢复。脑池内注射环己酰亚胺可阻止皮质酮对酶活性的恢复作用。给肾上腺切除的大鼠注射环己酰亚胺会导致酶活性进一步降低，这表明即使在没有皮质酮的情况下，该酶也有快速的周转。
