Francesconi R P, Mager M
Science. 1969 Dec 12;166(3911):1412-3. doi: 10.1126/science.166.3911.1412.
Despite a reduction in liver and body weights of neonatal rats born and reared at a simulated altitude of 5790 meters (oxygen pressure, 76.36 millimeters of mercury), the hepatic enzyme tryptophan oxygenase develops prematurely in these stressed animals as compared to controls reared at sea level. Also, the specific activities remain distinctly elevated through the first 9 days of age; thus, the competence for premature synthesis ot tryptophan oxygenase is confirmed in neonatal rats.
尽管在模拟海拔5790米（氧气压力为76.36毫米汞柱）环境下出生并饲养的新生大鼠肝脏和体重有所减轻，但与在海平面饲养的对照组相比，这些应激动物体内的肝脏酶色氨酸加氧酶过早发育。此外，在出生后的前9天，其比活性仍明显升高；因此，新生大鼠体内色氨酸加氧酶过早合成的能力得到了证实。
