Riecanský I, Haviar V, Plachá L
Cor Vasa. 1979;21(3):176-88.
A phonocardiological analysis of the first heart sound was made and systolic time intervals were measured in 40 patients (ischaemic heart disease, hypertensive heart disease, cardiomyopathies) with incipient cardiac failure (functional groups I--II according to the NYHA) with auscultatory changes of the first heart sound and in controls of randomly selected healthy persons or patients in whom cardiopulmonary disease was excluded. The patients in all diagnostic groups differed significantly (P less than 0.05--0.001) in practically all the phonocardiographic indicators from the controls. The most constant abnormal finding was a pathological split of the first heart sound which may be divided into three phonocardiographic forms. Simultaneously, systolic time intervals alterations (P less than 0.02--0.001) were also found in these patients and indicated a lowered performance of the left ventricle. The results suggest that 1) a certain relation exists between systolic time intervals and the phonocardiographic pattern of the first heart sound in patients with cardiovascular diseases and those without it; 2) the modified (pathologically splitted and prolonged) first heart sound could be a sign of incipient cardiac failure.
对40例初发心力衰竭（根据纽约心脏协会心功能分级为Ⅰ-Ⅱ级）且第一心音有听诊改变的患者（包括缺血性心脏病、高血压性心脏病、心肌病患者）以及随机选取的健康对照者或排除心肺疾病的患者进行了第一心音的心音图分析，并测量了收缩期时间间期。所有诊断组的患者在几乎所有的心音图指标上与对照组相比均有显著差异（P<0.05-0.001）。最常见的异常发现是第一心音病理性分裂，可分为三种心音图形式。同时，这些患者也存在收缩期时间间期改变（P<0.02-0.001），提示左心室功能降低。结果表明：1）心血管疾病患者和非心血管疾病患者的收缩期时间间期与第一心音的心音图模式之间存在一定关系；2）改变的（病理性分裂和延长的）第一心音可能是初发心力衰竭的一个征象。
