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Br Med J. 1969 Nov 22;4(5681):461-6. doi: 10.1136/bmj.4.5681.461.
2
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引用本文的文献

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本文引用的文献

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Treatment of Malaria with cortisone.用可的松治疗疟疾。
U S Armed Forces Med J. 1952 Sep;3(9):1347-52.
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Cortisone and Plasmodium berghei infection in mice.可的松与小鼠伯氏疟原虫感染
Nature. 1952 Mar 29;169(4300):547. doi: 10.1038/169547a0.
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The influence of cortisone on primate malaria.可的松对灵长类疟疾的影响。
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CONSIDERATION OF SOME ASPECTS OF HUMAN MALARIA.关于人类疟疾某些方面的思考
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MALARIAL ANTIBODIES IN IDIOPATHIC SPLENOMEGALY IN UGANDA.乌干达特发性脾肿大中的疟疾抗体
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HAEMOLYTIC ANAEMIA FOLLOWING MALARIAL THERAPY.疟疾治疗后溶血性贫血
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7
Fluorescent antibody staining as a measure of malarial antibody.荧光抗体染色作为疟疾抗体的一种检测方法。
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Exchange transfusion in treatment of servere anaemia in pregnancy.换血疗法治疗妊娠重度贫血
Lancet. 1962 Jan 13;1(7220):75-8. doi: 10.1016/s0140-6736(62)91722-1.
9
Gamma-globulin and acquired immunity to human malaria.γ-球蛋白与人类疟疾的获得性免疫
Nature. 1961 Nov 25;192:733-7. doi: 10.1038/192733a0.
10
Studies on the folic acid activity of human serum.人体血清叶酸活性的研究。
J Clin Pathol. 1961 Jul;14(4):335-44. doi: 10.1136/jcp.14.4.335.

在尼日利亚接受泼尼松龙治疗的孕妇中的严重溶血性贫血。

Severe haemolytic anaemia in pregnancy in Nigerians treated with prednisolone.

作者信息

Fleming A F, Allan N C

出版信息

Br Med J. 1969 Nov 22;4(5681):461-6. doi: 10.1136/bmj.4.5681.461.

DOI:10.1136/bmj.4.5681.461
PMID:5354835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1630524/
Abstract

Haemolytic anaemia of obscure aetiology is a common complication of pregnancy in Nigeria. Treatment with antimalarials and folic acid is usually followed by a rapid remission, but response is slow in about 25% of patients and haemolysis continues uncontrolled in about 5%. The administration of prednisolone to six patients with uncontrolled haemolysis was followed by rapid recovery in five and possible benefit in one. Risks of prednisolone therapy to the mother appear to be slight and outweighed by the risks of continued severe anaemia and frequent blood transfusions. There seemed to be no appreciable increase of fetal loss compared with that in anaemic pregnancies not treated with prednisolone.

摘要

病因不明的溶血性贫血是尼日利亚妊娠期常见的并发症。使用抗疟药和叶酸治疗后通常会迅速缓解,但约25%的患者反应缓慢,约5%的患者溶血持续且无法控制。对6例溶血未得到控制的患者给予泼尼松龙治疗后,5例迅速康复,1例可能获益。泼尼松龙治疗对母亲的风险似乎较小,且与持续严重贫血和频繁输血的风险相比,前者更为轻微。与未用泼尼松龙治疗的贫血妊娠相比,胎儿丢失似乎没有明显增加。