Cuthbert M F
Br Med J. 1969 Dec 20;4(5685):723-6. doi: 10.1136/bmj.4.5685.723.
The forced expiratory volume in one second (F.E.V.(1)) was measured in healthy and asthmatic volunteers and the inhalation of prostaglandin E(1) (PGE(1)) was compared with that of isoprenaline, using metered aerosols.In healthy volunteers PGE(1), either as the free acid or the neutral triethanolamine salt, did not affect the F.E.V.(1); the free acid was irritant to the upper respiratory tract. In five out of six asthmatic volunteers with reversible airways obstruction, inhalation of 55 mug of PGE(1) (triethanolamine salt) produced an increase in F.E.V.(1) comparable in both degree and duration to that produced by an inhalation of 550 mug. of isoprenaline sulphate.Though the triethanolamine salt was well tolerated in most of the asthmatic subjects studied, in one asthmatic subject this preparation caused coughing and there was a progressive reduction in the F.E.V.(1) associated with bronchospasm.
对健康志愿者和哮喘志愿者测量了一秒用力呼气量（F.E.V.(1)），并使用定量气雾剂将前列腺素E(1)（PGE(1)）的吸入情况与异丙肾上腺素进行了比较。在健康志愿者中，游离酸形式或中性三乙醇胺盐形式的PGE(1)均不影响F.E.V.(1)；游离酸对上呼吸道有刺激性。在六名患有可逆性气道阻塞的哮喘志愿者中，有五名吸入55微克PGE(1)（三乙醇胺盐）后，F.E.V.(1)的增加在程度和持续时间上与吸入550微克硫酸异丙肾上腺素所产生的增加相当。尽管在大多数所研究的哮喘受试者中三乙醇胺盐耐受性良好，但在一名哮喘受试者中，该制剂引起了咳嗽，并且F.E.V.(1)随着支气管痉挛逐渐降低。
