前列腺素F(2)α和E(2)气雾剂对人支气管肌张力的拮抗作用
Antagonistic Action of Aerosols of Prostaglandins F(2)alpha and E(2) on Bronchial Muscle Tone in Man.
作者信息
Smith A P, Cuthbert M F
出版信息
Br Med J. 1972 Jul 22;3(5820):212-3. doi: 10.1136/bmj.3.5820.212.
Experiments were carried out in healthy male volunteers to investigate the effect of the inhalation of prostaglandin F(2)alpha (PGF(2)alpha) on airways resistance and the influence of the subsequent inhalation of prostaglandin E(2) (PGE(2)). Airways resistance, which reflects the tone of smooth muscle in the larger airways in man, was measured by total body plethysmography.The inhalation of PGF(2)alpha (40-60 mug) caused an increase in airways resistance in all subjects. Both PGE(2) (55 mug) and isoprenaline (550 mug) given by metered aerosol promptly reversed the bronchoconstriction induced by PGF(2)alpha, but isoprenaline was more effective in this respect.A role for these prostaglandins in the control of bronchial muscle tone is discussed.
在健康男性志愿者身上进行了实验，以研究吸入前列腺素F(2)α（PGF(2)α）对气道阻力的影响以及随后吸入前列腺素E(2)（PGE(2)）的影响。气道阻力反映了人类较大气道中平滑肌的张力，通过全身体积描记法进行测量。吸入PGF(2)α（40 - 60微克）导致所有受试者的气道阻力增加。通过定量气雾剂给予的PGE(2)（55微克）和异丙肾上腺素（550微克）都能迅速逆转PGF(2)α引起的支气管收缩，但在这方面异丙肾上腺素更有效。讨论了这些前列腺素在控制支气管肌张力中的作用。
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