Jurgens-van der Zee A D, Bierman-van Eendenburg M E, Fidler V J, Olinga A A, Visch J H, Touwen B C, Huisjes H J
Early Hum Dev. 1979 Jul;3(2):141-54. doi: 10.1016/0378-3782(79)90003-3.
The Groningen Perinatal Project is a follow-up study relating pre- and perinatal conditions to early and late neurological sequelae. A description is given of the first cohort of 1507 children, examined neurologically during the neonatal period, and of their mothers and their pregnancies. In this preliminary analysis three 'final pathways' are considered, i.e. intrauterine growth retardation, preterm birth and acidemia (pH in umbilical vein below 7.20). Significant relationships were found between the 'final pathways' and the neurological findings. Since, however, these relationships account for only a small part of the variance of the latter, it is concluded that the (cumulative) effect of other antenatal variables must be taken into account as well. Results of analyses to this effect will be reported in forthcoming publications.
格罗宁根围产期项目是一项将产前和围产期状况与早期及晚期神经后遗症相关联的随访研究。本文描述了首批1507名儿童及其母亲和她们的孕期情况，这些儿童在新生儿期接受了神经学检查。在这项初步分析中，考虑了三条“最终路径”，即宫内生长迟缓、早产和酸血症（脐静脉pH值低于7.20）。研究发现“最终路径”与神经学检查结果之间存在显著关联。然而，由于这些关联仅占后者方差的一小部分，因此得出结论，还必须考虑其他产前变量的（累积）影响。关于这方面分析的结果将在后续出版物中报告。
