Piper J M, Xenakis E M, McFarland M, Elliott B D, Berkus M D, Langer O
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, USA.
Obstet Gynecol. 1996 Feb;87(2):169-74. doi: 10.1016/0029-7844(95)00400-9.
To determine if perinatal morbidity and mortality differ in growth-retarded, small for gestational age (SGA), premature infants and appropriate for gestational age (AGA) infants.
All consecutive, singleton, nondiabetic, preterm pregnancies delivered over a 15-year period were analyzed. Infants were categorized as SGA (at or below the tenth percentile) or AGA (11th to the 89th percentiles), then stratified by birth weight and gestational age categories. Perinatal morbidity and mortality were examined.
We studied 4183 preterm deliveries, 1012 of them SGA and 3171 of them AGA. Overall, we found significantly higher rates of fetal and neonatal death in the SGA group. Stratification by gestational age revealed significantly higher rates of neonatal death for the SGA group compared with the AGA group in each gestational age category. Overall, comparison also revealed significantly higher rates of fetal heart rate abnormality in the SGA group but no difference in neonatal sepsis, birth trauma, cesarean delivery, hyaline membrane disease, or congenital anomalies.
Growth-retarded premature infants have a significantly higher risk of morbidity and mortality, both before and after delivery, than do appropriately grown infants.
确定生长受限的小于胎龄（SGA）早产儿与适于胎龄（AGA）婴儿的围产期发病率和死亡率是否存在差异。
对15年间所有连续单胎、非糖尿病的早产妊娠进行分析。婴儿被分为SGA（处于或低于第十百分位数）或AGA（第11至89百分位数），然后按出生体重和胎龄类别进行分层。对围产期发病率和死亡率进行检查。
我们研究了4183例早产分娩，其中1012例为SGA，3171例为AGA。总体而言，我们发现SGA组的胎儿和新生儿死亡率显著更高。按胎龄分层显示，在每个胎龄类别中，SGA组的新生儿死亡率均显著高于AGA组。总体比较还显示，SGA组的胎儿心率异常发生率显著更高，但在新生儿败血症、产伤、剖宫产、透明膜病或先天性异常方面无差异。
生长受限的早产儿在分娩前后的发病率和死亡率风险均显著高于生长正常的婴儿。
