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蛋白质与胰岛素释放：氨基酸和肠道激素的双重作用

Proteins and insulin release: a dual role of amino-acids and intestinal hormones.

作者信息

Jarrett R J, Graver H J, Cohen N M

出版信息

Br Med J. 1969 Dec 6;4(5683):598-600. doi: 10.1136/bmj.4.5683.598.

DOI:10.1136/bmj.4.5683.598
PMID:5356549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1630076/
Abstract

In two subjects concurrent infusion of amino-acids and the hormones secretin and pancreozymin provoked much higher plasma insulin levels than did administration of amino-acids or hormones individually. It is suggested that this may be a physiological phenomenon, augmenting the release of insulin from the pancreas after a meal containing protein.

摘要

在两名受试者中，同时输注氨基酸与激素促胰液素和缩胆囊素所引起的血浆胰岛素水平，比单独给予氨基酸或激素时要高得多。有人认为，这可能是一种生理现象，在摄入含蛋白质的餐后可增强胰腺胰岛素的释放。

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1
Proteins and insulin release: a dual role of amino-acids and intestinal hormones.蛋白质与胰岛素释放：氨基酸和肠道激素的双重作用
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2
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Diabetologia. 1971 Apr;7(2):68-72. doi: 10.1007/BF00443883.
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引用本文的文献

1
The mechanism of insulin secretion after oral glucose administration. I. Multiphasic course of insulin mobilization after oral administration of glucose in conscious dogs. Differences to the behaviour after intravenous administration.口服葡萄糖后胰岛素分泌的机制。I. 清醒犬口服葡萄糖后胰岛素动员的多相过程。与静脉注射后行为的差异。
Diabetologia. 1972 Apr;8(2):104-10. doi: 10.1007/BF01235634.

本文引用的文献

1
Physiological determination of release of secretin and pancreozymin from intestine of dogs with transplanted pancreas.移植胰腺犬肠道中促胰液素和缩胆囊素释放的生理学测定
Am J Physiol. 1951 Feb;164(2):527-45. doi: 10.1152/ajplegacy.1951.164.2.527.
2
The effect of amino acid-glucose infusions upon the serum amino acid and blood sugar concentrations in viral hepatitis.氨基酸 - 葡萄糖输注对病毒性肝炎患者血清氨基酸及血糖浓度的影响。
J Lab Clin Med. 1955 Oct;46(4):560-7.
3
Intestinal hormones and plasma-insulin. Some observations on glucagon, secretin, and gastrin.肠激素与血浆胰岛素。关于胰高血糖素、促胰液素和胃泌素的一些观察
Lancet. 1967 Oct 21;2(7521):861-3. doi: 10.1016/s0140-6736(67)92594-9.
4
Intestinal hormones and plasma insulin: an insulinotropic action of secretin.肠激素与血浆胰岛素：促胰液素的促胰岛素作用。
Br Med J. 1967 Jun 10;2(5553):676-8. doi: 10.1136/bmj.2.5553.676.
5
Effects of Co-ingestion of fat and protein upon carbohydrate-induced hyperglycemia.脂肪与蛋白质共同摄入对碳水化合物诱导的高血糖的影响。
Diabetes. 1967 Apr;16(4):232-7. doi: 10.2337/diab.16.4.232.
6
Critical analysis of blood sugar measurements in diabetes detection and diagnosis.糖尿病检测与诊断中血糖测量的批判性分析。
Diabetes. 1967 Apr;16(4):219-26. doi: 10.2337/diab.16.4.219.
7
Insulin response to ingested protein in diabetes.糖尿病患者对摄入蛋白质的胰岛素反应。
Diabetes. 1966 May;15(5):303-6. doi: 10.2337/diab.15.5.303.
8
Insulin secretion in response to protein ingestion.蛋白质摄入后胰岛素的分泌。
J Clin Invest. 1966 Sep;45(9):1479-86. doi: 10.1172/JCI105455.
9
Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids.循环胰高血糖素对十二指肠内和静脉注射氨基酸反应的特征分析。
J Clin Invest. 1968 Oct;47(10):2305-22. doi: 10.1172/JCI105916.
10
Failure of endogenous stimulation of secretin and pancreozymin release to influence serum-insulin.
Lancet. 1968 Mar 2;1(7540):448-51. doi: 10.1016/s0140-6736(68)92780-3.