Dupre J, Curtis J D, Unger R H, Waddell R W, Beck J C
J Clin Invest. 1969 Apr;48(4):745-57. doi: 10.1172/JCI106032.
Intravenous administration of porcine secretin or pancreozymin or synthetic human gastrin II resulted in raised increments in serum immunoreactive insulin during intravenous infusion of glucose in normal man. Enhancement of serum immunoreactive insulin by each hormone was associated with accelerated disposal of glucose. In response to prolonged intravenous infusion of arginine with pancreozymin there was a maintained rise in immunoreactive insulin and glucagon-like immunoreactivity in the blood. These effects of pancreozymin and arginine were not reproduced with secretin and arginine, and may have been due to the stimulation of glucagon secretion together with insulin by pancreozymin. Enteric infusion of hydrochloric acid, or stimulation of gastric acid secretion by betazole, presumed to cause release of endogenous secretin, led to enhancement of insulin secretion during intravenous infusion of glucose. Enteric infusion of arginine, presumed to cause release of endogenous pancreozymin, led to a rise in serum immunoreactive insulin not attributable to effects of circulating glucose and amino acids. It is concluded that secretin and pancreozymin released in response to physiological stimuli contribute to stimulation of the endocrine pancreas after ingestion of food.
在正常人体内静脉输注葡萄糖期间，静脉注射猪促胰液素、胰酶泌素或合成人胃泌素II会导致血清免疫反应性胰岛素水平升高。每种激素对血清免疫反应性胰岛素的增强作用与葡萄糖的加速代谢相关。在静脉长时间输注精氨酸并同时输注胰酶泌素时，血液中免疫反应性胰岛素和胰高血糖素样免疫反应性持续升高。促胰液素和精氨酸的这些作用在促胰液素和精氨酸组合时并未重现，这可能是由于胰酶泌素同时刺激了胰高血糖素和胰岛素的分泌。肠道输注盐酸，或用倍他唑刺激胃酸分泌（推测可引起内源性促胰液素释放），会导致静脉输注葡萄糖期间胰岛素分泌增强。肠道输注精氨酸（推测可引起内源性胰酶泌素释放）会导致血清免疫反应性胰岛素升高，这并非由循环中的葡萄糖和氨基酸的作用所致。结论是，对生理刺激做出反应而释放的促胰液素和胰酶泌素在摄入食物后有助于刺激内分泌胰腺。
