Doi K, Kuroshima A
Life Sci. 1982 Mar 1;30(9):785-91. doi: 10.1016/0024-3205(82)90614-2.
Calorigenic effect of glucagon on whole body oxygen consumption and interscapular brown adipose tissue (BAT) was investigated in unanesthetized and unrestrained warm controls (WC), cold-acclimated rats (CA) and heat-acclimated rats (HA). Glucagon produced significant elevation of oxygen consumption, body temperature and BAT temperature in all experimental groups. Such increased calorigenic responses to glucagon were significantly potentiated in CA and reduced in HA compared with those in WC. Thermogenic response of BAT to norepinephrine was also similar to that to glucagon; it was potentiated in CA, reduced in HA. These results indicate that glucagon would serve thermoregulatory nonshivering thermogenesis in temperature acclimation as calorigenic hormone, at least in part, through its action on BAT.
在未麻醉且不受限制的温暖对照组（WC）、冷适应大鼠（CA）和热适应大鼠（HA）中，研究了胰高血糖素对全身耗氧量和肩胛间棕色脂肪组织（BAT）的产热作用。胰高血糖素使所有实验组的耗氧量、体温和BAT温度显著升高。与WC组相比，CA组对胰高血糖素的这种产热反应增强，而HA组则减弱。BAT对去甲肾上腺素的产热反应也与对胰高血糖素的反应相似；在CA组中增强，在HA组中减弱。这些结果表明，胰高血糖素至少部分地通过其对BAT的作用，作为产热激素在温度适应中发挥体温调节性非寒战产热作用。
