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胰高血糖素与急性心肌梗死的血流动力学

Glucagon and haemodynamics of acute myocardial infarction.

作者信息

Eddy J D, O'Brien E T, Singh S P

出版信息

Br Med J. 1969 Dec 13;4(5684):663-5. doi: 10.1136/bmj.4.5684.663.

DOI:10.1136/bmj.4.5684.663
PMID:5359922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1630192/
Abstract

Glucagon was administered to six patients with acute myocardial infarction. Three of them had cardiogenic shock syndrome. Glucagon produced a positive inotropic response in all cases, which resulted in a significant rise in blood pressure, with only slight chronotropic effect. No arrhythmias were induced, and all patients with cardiogenic shock improved temporarily. Further evaluation of glucagon in shock syndrome to determine the dose and method of administration is required.

摘要

对6例急性心肌梗死患者使用了胰高血糖素。其中3例患有心源性休克综合征。胰高血糖素在所有病例中均产生了正性肌力反应，导致血压显著升高，而变时作用轻微。未诱发心律失常，所有心源性休克患者均暂时好转。需要进一步评估胰高血糖素在休克综合征中的作用，以确定给药剂量和方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/1630192/cb4f0094c276/brmedj02062-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/1630192/cb4f0094c276/brmedj02062-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04a0/1630192/cb4f0094c276/brmedj02062-0055-a.jpg

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1
Glucagon and haemodynamics of acute myocardial infarction.胰高血糖素与急性心肌梗死的血流动力学
Br Med J. 1969 Dec 13;4(5684):663-5. doi: 10.1136/bmj.4.5684.663.
2
Acute myocardial infarction in man. Comparative hemodynamic effects of norepinephrine and glucagon.
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Effects of glucagon on myocardial contractility and hemodynamics in acute experimental myocardial infarction. Basis for its possible use in cardiogenic shock.胰高血糖素对急性实验性心肌梗死心肌收缩力和血流动力学的影响。其在心源性休克中可能应用的依据。
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Haemodynamic effects of glucagon during acute myocardial infarction with left ventricular failure in man.胰高血糖素对人急性心肌梗死合并左心室衰竭时的血流动力学影响。
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引用本文的文献

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Role of Glucagon in Automated Insulin Delivery.胰高血糖素在自动化胰岛素输送中的作用。
Endocrinol Metab Clin North Am. 2020 Mar;49(1):179-202. doi: 10.1016/j.ecl.2019.10.008. Epub 2019 Dec 10.
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Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction.心肌细胞胰高血糖素受体信号转导调节实验性心肌梗死小鼠的结局。
Mol Metab. 2014 Nov 29;4(2):132-43. doi: 10.1016/j.molmet.2014.11.005. eCollection 2015 Feb.
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Haemodynamic effects of glucagon during acute myocardial infarction with left ventricular failure in man.

本文引用的文献

1
The treatment of cardiogenic shock. II. The use of pressor agents in the treatment of cardiogenic shock.心源性休克的治疗。II. 升压药在心源性休克治疗中的应用。
Am Heart J. 1967 Nov;74(5):725-8. doi: 10.1016/0002-8703(67)90511-x.
2
Glucagon. Its enhancement of cardiac performance in the cat and dog and persistence of its inotropic action despite beta-receptor blockade with propranolol.胰高血糖素。它对猫和狗心脏功能的增强作用，以及尽管用普萘洛尔进行β受体阻滞但其正性肌力作用仍持续存在。
Circ Res. 1968 Jun;22(6):789-99. doi: 10.1161/01.res.22.6.789.
3
Glucagon therapy in heart-failure.
胰高血糖素对人急性心肌梗死合并左心室衰竭时的血流动力学影响。
Br Heart J. 1971 Mar;33(2):290-5. doi: 10.1136/hrt.33.2.290.
4
Comparison of the inotropic response to glucagon, ouabain and noradrenaline.胰高血糖素、哇巴因和去甲肾上腺素的变力性反应比较。
Br J Pharmacol. 1970 Nov;40(3):382-95. doi: 10.1111/j.1476-5381.1970.tb10620.x.
5
Effect of glucagon on ventricular arrhythmias after coronary artery occlusion and on ventricular automaticity in the dog.胰高血糖素对犬冠状动脉闭塞后室性心律失常及心室自律性的影响。
Br J Pharmacol. 1971 Oct;43(2):279-86.
6
Effect of glucagon on left ventricular performance in aortic stenosis.胰高血糖素对主动脉瓣狭窄患者左心室功能的影响。
Br Heart J. 1973 Mar;35(3):312-9. doi: 10.1136/hrt.35.3.312.
心力衰竭中的胰高血糖素治疗。
Lancet. 1969 Mar 8;1(7593):482-4. doi: 10.1016/s0140-6736(69)91587-6.