Kauffmann F, Drouet D, Lellouch J, Brille D
Int J Epidemiol. 1979 Sep;8(3):201-12. doi: 10.1093/ije/8.3.201.
The effects of smoking habits, socio-occupational factors and respiratory symptoms in the development of airflow obstruction have been studied in a working population of 575 men aged 30-54 in 1960 and surveyed in 1960 and 1972. On average, FEV1 decreased by 47 ml/annum. Apart from FEV1 level, which reflects loss since the beginning of adult life, three factors were independently related to FEV1 slope: tobacco consumption, occupational exposure and social class. The decrease of FEV1 with smoking was dose related and decelerated among those who stopped smoking. This follow-up study ruled against phlegm as a causal factor of early stage airflow obstruction, although its role is not excluded at later stages.
1960年，对575名年龄在30至54岁之间的男性在职人群的吸烟习惯、社会职业因素和呼吸道症状对气流阻塞发展的影响进行了研究，并在1960年和1972年进行了调查。平均而言，第一秒用力呼气容积（FEV1）每年下降47毫升。除了反映成年生活开始以来肺功能损失的FEV1水平外，有三个因素与FEV1下降斜率独立相关：烟草消费、职业暴露和社会阶层。FEV1随吸烟的下降与剂量相关，且在戒烟者中下降速度减缓。这项随访研究排除了痰液作为早期气流阻塞病因的可能性，尽管不排除其在后期阶段的作用。
