Saleh J W, Yang M U, van Itallie T B, Hashim S A
Int J Obes. 1979;3(3):213-21.
The effect of cyproheptadine on spontaneous energy intake was studied by means of an automated (liquid diet) food-dispensing apparatus in two nonobese adults confined to a metabolic ward. The experimental design included both single and double-blind periods. Throughout, the composition of daily weight change was determined by the energy-nitrogen balance method. While on cyproheptadine, both subjects exhibited increases in energy intake with the following average composition of weight gain: protein 16%, fat 14% and water 70% (first subject), and protein 5%, fat 49% and water 46% (second subject). The cyproheptadine-induced increase in energy intake was statistically significant in one of the subjects, who was at his desirable weight level at the outset. The other subject was underweight initially and tended to gain throughout the experiment, although rate of weight gain appeared to be more rapid during the periods of cyproheptadine administration. Energy output in both subjects remained fairly constant throughout. We conclude that cyproheptadine induces weight gain of 'normal' composition by stimulating increased energy intake.
通过自动（流食）食物分配装置，在两名被限制在代谢病房的非肥胖成年人中研究了赛庚啶对自发能量摄入的影响。实验设计包括单盲期和双盲期。在整个过程中，通过能量 - 氮平衡法确定每日体重变化的组成。服用赛庚啶期间，两名受试者的能量摄入均增加，体重增加的平均组成如下：蛋白质16%、脂肪14%和水70%（第一名受试者），以及蛋白质5%、脂肪49%和水46%（第二名受试者）。在其中一名初始体重处于理想水平的受试者中，赛庚啶引起的能量摄入增加具有统计学意义。另一名受试者最初体重过轻，在整个实验过程中倾向于体重增加，尽管在服用赛庚啶期间体重增加速度似乎更快。两名受试者的能量输出在整个过程中保持相当稳定。我们得出结论，赛庚啶通过刺激能量摄入增加导致“正常”组成的体重增加。
