Sowers J R, Carlson H E, Brautbar N, Hershman J M
J Clin Endocrinol Metab. 1977 Feb;44(2):237-41. doi: 10.1210/jcem-44-2-237.
We studied the effects of administration of dexamethasone, 2 mg orally every 6 h, for 5 days on the thyrotropin-releasing hormone (TRH)-induced release of prolactin (PRL), thyrotropin (TSH), triiodothyronine (T3) and thyroxine (T4) in 9 normal men and on the metoclopramide-induced release of PRL in 7 normal men. Dexamethasone suppressed the baseline serum levels of PRL, TSH and T3. The administration of dexamethasone blunted the PRL and TSH response to TRH; the blunted TSH response resulted in a decreased T3 and T4 response to TRH after dexamethasone. Following dexamethasone administration, the PRL response to metoclopramide, a dopamine antagonist which acts at the hypothalamicpituitary level to stimulate PRL secretion, was blunted in 7 normal men. The data suggest that short-term administration of pharmacological doses of glucocorticoids suppress the secretion of PRL and TSH by a direct effect on the anterior pituitary gland.
我们研究了对9名正常男性每6小时口服2毫克地塞米松，持续5天，对促甲状腺激素释放激素（TRH）诱导的催乳素（PRL）、促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）释放的影响，以及对7名正常男性胃复安诱导的PRL释放的影响。地塞米松抑制了PRL、TSH和T3的基础血清水平。地塞米松的给药减弱了PRL和TSH对TRH的反应；TSH反应减弱导致地塞米松后T3和T4对TRH的反应降低。地塞米松给药后，7名正常男性中，胃复安（一种作用于下丘脑 - 垂体水平刺激PRL分泌的多巴胺拮抗剂）诱导的PRL反应减弱。数据表明，短期给予药理剂量的糖皮质激素通过直接作用于垂体前叶抑制PRL和TSH的分泌。
