Perrudet-Badoux A, Frei P C
Clin Exp Immunol. 1969 Jul;5(1):117-27.
A method of immunocyto-adherence using circulating lymphocytes and sheep red cells coated with an antigen (rosette-formation) was studied in an attempt to detect lymphocytic antibodies. Human and experimental immune thyroiditis were chosen as a model. Such lymphocytic antibodies correlate better with the presence of immune thyroiditis than do humoral antibodies. The principal aim of the present study was to try to explain the significance of the rosette-forming lymphocyte. The different experiments carried out for instance with the addition of an immunosuppressive drug or trypsin suggest that this lymphocyte may be representative of delayed type hypersensitivity. Other experiments allowed us to think that this cell was unable to passively fix circulating antibodies.
研究了一种使用循环淋巴细胞和包被抗原的绵羊红细胞进行免疫细胞黏附的方法（玫瑰花结形成），以试图检测淋巴细胞抗体。选择人类和实验性免疫性甲状腺炎作为模型。与体液抗体相比，此类淋巴细胞抗体与免疫性甲状腺炎的存在相关性更好。本研究的主要目的是试图解释形成玫瑰花结的淋巴细胞的意义。例如，添加免疫抑制药物或胰蛋白酶进行的不同实验表明，这种淋巴细胞可能代表迟发型超敏反应。其他实验使我们认为这种细胞无法被动结合循环抗体。
