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1
Factors which determine the gastric secretory response to 2-deoxy-D-glucose.决定胃对2-脱氧-D-葡萄糖分泌反应的因素。
Gut. 1969 Dec;10(12):1015-9. doi: 10.1136/gut.10.12.1015.
2
Response of the pyloric and pyloric-oesophageal ligated rat to insulin and 2-deoxy-D-glucose.幽门及幽门-食管结扎大鼠对胰岛素和2-脱氧-D-葡萄糖的反应。
Aust J Exp Biol Med Sci. 1969 Jun;47(3):381-6. doi: 10.1038/icb.1969.41.
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Effect of graded doses of pentagastrin, histamine and 2-deoxy-D-glucose on gastric secretion and motility in conscious rats.不同剂量的五肽胃泌素、组胺和2-脱氧-D-葡萄糖对清醒大鼠胃分泌和运动的影响。
Scand J Gastroenterol. 1968;3(6):572-6.
4
Inhibition by gastrone of rat gastric acid secretion maximally stimulated by 2-deoxy-D-glucose.抑胃素对由2-脱氧-D-葡萄糖最大程度刺激的大鼠胃酸分泌的抑制作用。
Aust J Exp Biol Med Sci. 1967 Jun;45(3):327-9. doi: 10.1038/icb.1967.30.
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[Inhibition of gastric acid secretion in chickens by atropine, insulin and 2-deoxy-D-glucose].[阿托品、胰岛素和2-脱氧-D-葡萄糖对鸡胃酸分泌的抑制作用]
Naunyn Schmiedebergs Arch Pharmacol. 1972;273(3):219-29. doi: 10.1007/BF00501414.
6
Use of 2 deoxy-D-glucose to test for the completeness of surgical vagotomy.使用2-脱氧-D-葡萄糖检测手术切断迷走神经的完整性。
Gut. 1968 Feb;9(1):125-8. doi: 10.1136/gut.9.1.125.
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Inhibition of gastric acid secretion by insulin and 2-deoxy-D-glucose.胰岛素和2-脱氧-D-葡萄糖对胃酸分泌的抑制作用。
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The gastric secretory response to insulin: an 'all-or-none' phenomenon?胃对胰岛素的分泌反应：一种“全或无”现象？
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9
Site of action of 2-deoxy-D-glucose mediating gastric secretion in the cat.2-脱氧-D-葡萄糖介导猫胃分泌的作用部位。
J Physiol. 1972 Feb;221(1):1-13. doi: 10.1113/jphysiol.1972.sp009734.
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Rat gastric acid secretion in response to graded subcutaneous doses of 2-deoxy-D-glucose.大鼠对皮下注射不同剂量2-脱氧-D-葡萄糖的胃酸分泌反应。
Am J Physiol. 1966 Sep;211(3):626-8. doi: 10.1152/ajplegacy.1966.211.3.626.

引用本文的文献

1
[Inhibition of gastric acid secretion in chickens by atropine, insulin and 2-deoxy-D-glucose].[阿托品、胰岛素和2-脱氧-D-葡萄糖对鸡胃酸分泌的抑制作用]
Naunyn Schmiedebergs Arch Pharmacol. 1972;273(3):219-29. doi: 10.1007/BF00501414.
2
An assessment of the reproducibility and safety of 2-deoxy-D-glucose as a gastric acid stimulant in duodenal ulcer patients.2-脱氧-D-葡萄糖作为十二指肠溃疡患者胃酸刺激剂的重现性和安全性评估。
Gut. 1975 Mar;16(3):171-6. doi: 10.1136/gut.16.3.171.
3
Further studies on the mode of action of isoprenaline on gastric secretion in the conscious rat.关于异丙肾上腺素对清醒大鼠胃分泌作用方式的进一步研究。
Br J Pharmacol. 1976 Sep;58(1):17-25. doi: 10.1111/j.1476-5381.1976.tb07688.x.
4
Histamine metabolism of the guinea-pig gastric mucosa.豚鼠胃黏膜的组胺代谢
J Physiol. 1976 May;257(2):419-31. doi: 10.1113/jphysiol.1976.sp011376.

本文引用的文献

1
Increased adrenaline production following administration of 2-deoxy-D-glucose in the rat.大鼠注射2-脱氧-D-葡萄糖后肾上腺素分泌增加。
Proc Soc Exp Biol Med. 1961 Mar;106:537-9. doi: 10.3181/00379727-106-26394.
2
Facilitated transfer of glucose from blood into brain tissue.促进葡萄糖从血液向脑组织的转运。
J Physiol. 1965 Nov;181(1):103-13. doi: 10.1113/jphysiol.1965.sp007748.
3
The secretion of gastric acid in response to a lack of metabolizable glucose.因缺乏可代谢葡萄糖而产生的胃酸分泌。
J Physiol. 1969 May;202(1):97-109. doi: 10.1113/jphysiol.1969.sp008797.
4
Compensatory reactions to a lack of metabolizable glucose.对缺乏可代谢葡萄糖的代偿反应。
J Physiol. 1968 Sep;198(2):451-65. doi: 10.1113/jphysiol.1968.sp008616.
5
On the critical nature of blood sugar levels in the vagal stimulation of gastric acid secretion in normal and diabetic dogs.关于血糖水平在正常和糖尿病犬迷走神经刺激胃酸分泌中的关键性质。
Surgery. 1968 Nov;64(5):958-66.
6
Use of 2 deoxy-D-glucose to test for the completeness of surgical vagotomy.使用2-脱氧-D-葡萄糖检测手术切断迷走神经的完整性。
Gut. 1968 Feb;9(1):125-8. doi: 10.1136/gut.9.1.125.
7
The location of the chemoreceptor controlling gastric acid secretion during hypoglycaemia.低血糖期间控制胃酸分泌的化学感受器的位置。
Clin Sci. 1969 Oct;37(2):568.
8
Vagal gastric secretory stimulation by 2-deoxy-D-glucose.2-脱氧-D-葡萄糖对迷走神经的胃分泌刺激作用。
Am J Physiol. 1965 Sep;209(3):452-60. doi: 10.1152/ajplegacy.1965.209.3.452.

决定胃对2-脱氧-D-葡萄糖分泌反应的因素。

Factors which determine the gastric secretory response to 2-deoxy-D-glucose.

作者信息

Himsworth R L, Colin-Jones D G

出版信息

Gut. 1969 Dec;10(12):1015-9. doi: 10.1136/gut.10.12.1015.

DOI:10.1136/gut.10.12.1015
PMID:5370096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553020/
Abstract

The physiological factors which determine the penetration of the brain by 2-deoxy-D-glucose have been studied and the practical importance of the blood-brain barrier has been demonstrated. The evaluation of the gastric secretory response to 2-deoxy-D-glucose has been shown to depend upon the plasma glucose concentration. It is concluded that because of the hazards and uncertainties in the use of 2-deoxy-D-glucose in man its use is to be deprecated.

摘要

已对决定2-脱氧-D-葡萄糖进入大脑的生理因素进行了研究，并证明了血脑屏障的实际重要性。已表明对2-脱氧-D-葡萄糖的胃分泌反应评估取决于血浆葡萄糖浓度。得出的结论是，由于在人体中使用2-脱氧-D-葡萄糖存在风险和不确定性，因此不提倡使用。