Himsworth R L, Colin-Jones D G
Gut. 1969 Dec;10(12):1015-9. doi: 10.1136/gut.10.12.1015.
The physiological factors which determine the penetration of the brain by 2-deoxy-D-glucose have been studied and the practical importance of the blood-brain barrier has been demonstrated. The evaluation of the gastric secretory response to 2-deoxy-D-glucose has been shown to depend upon the plasma glucose concentration. It is concluded that because of the hazards and uncertainties in the use of 2-deoxy-D-glucose in man its use is to be deprecated.
已对决定2-脱氧-D-葡萄糖进入大脑的生理因素进行了研究,并证明了血脑屏障的实际重要性。已表明对2-脱氧-D-葡萄糖的胃分泌反应评估取决于血浆葡萄糖浓度。得出的结论是,由于在人体中使用2-脱氧-D-葡萄糖存在风险和不确定性,因此不提倡使用。