豚鼠胃黏膜的组胺代谢
Histamine metabolism of the guinea-pig gastric mucosa.
作者信息
Bergmark J, Granerus G, Henningsson S, Lundell L, Rosengren E
出版信息
J Physiol. 1976 May;257(2):419-31. doi: 10.1113/jphysiol.1976.sp011376.
Abstract
- The mobilization of gastric mucosal histamine as reflected by changes in formation and content has been studied in guinea-pigs on feeding and after injections of pentagastrin or 2-deoxy-D-glucose. 2. Re-feeding fasting guinea-pigs as well as injections of pentagastrin or 2-deoxy-D-glucose raised the rate of mucosal histamine formation; pentagastrin induced a fourfold rise. 3. Some properties of the enzyme catalysing the formation of histamine were examined. The results indicated that this enzyme is histidine decarboxylase, L-histidine carboxy-lyase, E.C. 4.1.1. 22. 4. The enzyme imidazole-N-methyl transferase, E.C. 2.1.1.8, which carries out methylation of the imidazole ring to yield 1-methyl-4-(beta-aminoethyl)imidazole (methylhistamine), was found in high amounts in the mucosa. The enzyme did not change upon stimulation of the mucosa. 5. The metabolism of histamine within the gastric mucosa is discussed in relationship to a suggested role of the amine in exciting acid secretion.
摘要
- 通过研究豚鼠进食后以及注射五肽胃泌素或2-脱氧-D-葡萄糖后组胺生成和含量的变化，来探讨胃黏膜组胺的动员情况。2. 再次喂食禁食的豚鼠以及注射五肽胃泌素或2-脱氧-D-葡萄糖均可提高黏膜组胺的生成速率；五肽胃泌素可使其升高四倍。3. 对催化组胺生成的酶的一些特性进行了研究。结果表明该酶是组氨酸脱羧酶，即L-组氨酸羧基裂解酶，酶编号为E.C. 4.1.1. 22。4. 在黏膜中发现大量的咪唑-N-甲基转移酶，即酶编号为E.C. 2.1.1.8的酶，它可使咪唑环甲基化生成1-甲基-4-（β-氨基乙基）咪唑（甲基组胺）。黏膜受到刺激后该酶无变化。5. 结合胺类在刺激胃酸分泌中可能的作用，对胃黏膜内组胺的代谢进行了讨论。
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本文引用的文献
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