Reddy E K, Mansfield C M, Hartman G V, Rouby E
J Natl Med Assoc. 1979 Oct;71(10):959-61.
Malignant salivary gland tumors are rare. They represent less than one percent of all head and neck tumors. Approximately three fourths of all salivary gland tumors occur in the major salivary glands.Traditionally, the treatment of choice for these tumors is surgery. The majority of these tumors reoccur after curative surgical procedures. Local recurrence rate following surgery varies with the histology, grade, and extent of the disease.In spite of high local recurrence rate following curative surgical treatment of these tumors, radiotherapy has seldom been used as an adjuvant to surgery. The value of elective postoperative radiation therapy for subclinical microscopic disease was not recognized. Review of the literature supports the improved local control rate with the use of immediate postoperative radiotherapy. Radiation therapy proved to be effective as an adjuvant to surgery. A local control rate of better than 40 percent can be achieved by radiation therapy as a sole modality in inoperable and locally advanced cases. Radiation therapy provides an excellent palliation for locally advanced tumors or symptomatic metastases.
恶性涎腺肿瘤较为罕见。它们在所有头颈部肿瘤中所占比例不到1%。所有涎腺肿瘤中约四分之三发生于大涎腺。传统上，这些肿瘤的首选治疗方法是手术。这些肿瘤中的大多数在根治性手术治疗后会复发。手术后的局部复发率因疾病的组织学类型、分级和范围而异。尽管这些肿瘤在根治性手术治疗后局部复发率很高，但放疗很少被用作手术的辅助治疗。选择性术后放疗对亚临床微小病变的价值尚未得到认可。文献回顾支持术后立即放疗可提高局部控制率。放疗被证明作为手术的辅助治疗是有效的。在无法手术和局部晚期病例中，放疗作为单一治疗方式可实现超过40%的局部控制率。放疗为局部晚期肿瘤或有症状的转移灶提供了良好的姑息治疗。
