二硝基甲苯的代谢与毒性研究。2,4-二硝基甲苯（2,4-DNT）对大鼠长期喂养的毒理学研究。
Studies on the metabolism and toxicity of dinitrotoluenes. Toxicological study of 2,4-dinitrotoluene (2, 4-DNT) in rats in long term feeding.
作者信息
Kozuka H, Mori M, Naruse Y
出版信息
J Toxicol Sci. 1979 Aug;4(3):221-8. doi: 10.2131/jts.4.221.
PMID:537127
Abstract
2, 4-Dinitrotoluene (2, 4-DNT) was incorporated at the level of 0.5% in a standard commercial diet and fed ad lib. to male rate for 6 months. Significant changes were noted in the body weight, organ weight, behavior, mortality, and biochemical analysis of blood and serum of rats ingesting 2, 4-DNT. Furthermore, it was found that the ingestion of 2, 4-DNT affected on the activities of drug metabolizing enzymes in liver microsomes.
摘要
将2,4-二硝基甲苯（2,4-DNT）以0.5%的比例掺入标准商业饲料中，随意喂食雄性大鼠6个月。在摄入2,4-DNT的大鼠的体重、器官重量、行为、死亡率以及血液和血清的生化分析方面发现了显著变化。此外，还发现摄入2,4-DNT会影响肝微粒体中药物代谢酶的活性。
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