Wise P H, Burnet R B, Ahmad A, Harding P E
Lancet. 1975 Dec 20;2(7947):1231-3. doi: 10.1016/s0140-6736(75)92071-1.
In a series of 50 cases of Graves' disease qualifying for therapy with radioiodine, "ablative" doses of radioiodine resulted in hypothyroidism in 92% of cases at six months. Hypothyroidism was treated by thyroxine or tri-iodothyronine replacement therapy. Rapid responses and predictable outcome were regarded as important advantages. Intentional ablation is particularly convenient in situations where clinical and biochemical follow-up may be difficult. Further follow-up studies are needed to determine whether ablative therapy is the treatment of choice in all cases of Graves' disease.
在一系列符合放射性碘治疗条件的50例格雷夫斯病患者中，“消融”剂量的放射性碘在六个月时导致92%的病例出现甲状腺功能减退。甲状腺功能减退通过甲状腺素或三碘甲状腺原氨酸替代疗法进行治疗。快速反应和可预测的结果被视为重要优势。在临床和生化随访可能困难的情况下，有意消融特别方便。需要进一步的随访研究来确定消融疗法是否是所有格雷夫斯病病例的首选治疗方法。
